Proposta de síntese e aplicação de novos aminoácidos fluorescentes

Abstract

Artificial fluorescent amino acids comprise a relevant class of organic compound due their properties and applications in many fields, such as sensors. In this monography, the incorporation of fluorescent nuclei in natural amino acids is contextualized. The functionalization of the building block 2,3-dichloroquinoxaline was emphasized as a powerful tool for the obtainment of modified amino acids via aromatic nucleophilic substitution. This approach allowed to suggest the synthesis of two novel amino acids (FAA1 and FAA2) functionalized with nitrogen heterocycles scaffold able present relevant fluorescent properties. These novel amino acids are planed to synthesized and applied in the field of sensors, as well as toxic agents against harmful bacteria and cancer cells, as well as in the detection of microorganisms.