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Title: Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review
Authors: Nascimento, Amanda Maria de Souza
Segundo, Victor Hugo de Oliveira
Aguiar, Ana Julia Felipe Camelo
Piuvezam, Grasiela
Passos, Tha ıs Souza
Damasceno, Karla Suzanne Florentino da Silva Florentino da Silva Chaves
Morais, Ana Heloneida de Araujo
Keywords: Antimicrobial peptides;bioactive proteins;bacteria;infectious diseases
Issue Date: 2022
Publisher: Taylor & Francis Group
Citation: NASCIMENTO, Amanda Maria de Souza et al. Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review. Journal of Enzyme Inhibition and Medicinal Chemistry, v. 37, n. 1, p. 749-759, 2022.
Portuguese Abstract: This systematic review (SR) aimed to gather studies describing the antibacterial action mechanisms and mode of trypsin inhibitors. The review protocol was registered (PROSPERO: CRD42020189069). Original articles resulting from studies in animal models, in bacterial culture, and using cells that describe antibac terial action of trypsin inhibitor-type peptides or proteins were selected in PubMed, Science Direct, Scopus, Web of Science, BVS, and EMBASE. The methodological quality assessment was performed using the PRISMA and OHAT tool. 2382 articles were retrieved, 17 of which were eligible. Four studies demon strated the action mechanism directly on the bacterial membrane, and the fifth study on endogenous pro teases extracted from the bacteria themselves. The antibacterial action mode was presented in the other studies, which can generate bacteriostatic or bactericidal effects without describing the mechanisms. This study generated information to enable new preclinical or clinical studies with molecules contributing to public health
Appears in Collections:CCS - DNUT - Artigos publicados em periódicos

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