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https://repositorio.ufrn.br/handle/123456789/52529| Title: | Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review |
| Authors: | Nascimento, Amanda Maria de Souza Segundo, Victor Hugo de Oliveira Aguiar, Ana Julia Felipe Camelo Piuvezam, Grasiela Passos, Tha ıs Souza Damasceno, Karla Suzanne Florentino da Silva Florentino da Silva Chaves Morais, Ana Heloneida de Araujo |
| Keywords: | Antimicrobial peptides;bioactive proteins;bacteria;infectious diseases |
| Issue Date: | 2022 |
| Publisher: | Taylor & Francis Group |
| Citation: | NASCIMENTO, Amanda Maria de Souza et al. Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review. Journal of Enzyme Inhibition and Medicinal Chemistry, v. 37, n. 1, p. 749-759, 2022. |
| Portuguese Abstract: | This systematic review (SR) aimed to gather studies describing the antibacterial action mechanisms and mode of trypsin inhibitors. The review protocol was registered (PROSPERO: CRD42020189069). Original articles resulting from studies in animal models, in bacterial culture, and using cells that describe antibac terial action of trypsin inhibitor-type peptides or proteins were selected in PubMed, Science Direct, Scopus, Web of Science, BVS, and EMBASE. The methodological quality assessment was performed using the PRISMA and OHAT tool. 2382 articles were retrieved, 17 of which were eligible. Four studies demon strated the action mechanism directly on the bacterial membrane, and the fifth study on endogenous pro teases extracted from the bacteria themselves. The antibacterial action mode was presented in the other studies, which can generate bacteriostatic or bactericidal effects without describing the mechanisms. This study generated information to enable new preclinical or clinical studies with molecules contributing to public health |
| URI: | https://repositorio.ufrn.br/handle/123456789/52529 |
| Appears in Collections: | CCS - DNUT - Artigos publicados em periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Antibacterialactionmechanisms_Nascimento_2022.pdf | 2 MB | Adobe PDF | View/Open |
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