Aplicação local sobre o esmalte de substâncias medicamentosas para a prevenção e controle da inflamação pulpar e suas sequelas: uma revisão de escopo

Abstract

Introduction: There must still be an evidence synthesis study about preventing and treating pulp inflammation and bleaching sensitivity using drugs applied to the enamel. Our scoping review aimed: (1) to map the drugs applied to the enamel to prevent and treat pulp inflammation and bleaching sensitivity; (2) to establish the evidence level of the efficacy of applying drugs to the enamel to prevent and treat pulp inflammation and bleaching sensitivity. Methodology: Two calibrated reviewers independently searched Pubmed, Web of Science, Scopus and Embase databases and included primary studies in humans and animals without time or language restrictions. Results: The final sample consisted of seven articles. All primary studies reported using otosporin, ibuprofen, dipyrone, eugenol and carvedilol in gel or liquid form, and in some cases in nanostructured form. The animal studies showed statistically significant efficacy in reducing the tooth bleaching-mediated inflammatory infiltrate in the pulp of Winstar rats using carvedilol, otosporin, and ibuprofen. The clinical studies showed no statistically significant difference in the risk and intensity of bleaching sensitivity using dipyrone, otosporin and eugenol on enamel. The use of the drugs also did not decrease the peroxide bleaching potential. Conclusion: Although the application of drugs to the enamel showed a positive post-bleaching anti-inflammatory effect in animals, studies in humans reported no reduction in bleaching sensitivity. We recommend that researchers evaluate permeability in human teeth and the clinical efficacy of nanostructured formulations in further studies.