1. Universidade Federal do Rio Grande do Norte
2. Centro de Ciências da Saúde
3. DNUT - Departamento de Nutrição
4. CCS - DNUT - Artigos publicados em periódicos

Título:	Retinol Levels and Severity of Patients with COVID-19
Autor(es):	Ribeiro, Karla Danielly da Silva Carvalho, Maria Clara da Cruz Araujo, Júlia Kaline Carvalho Pereira Silva, Ana Gabriella Costa Lemos da Silva, Nayara Sousa da Araújo, Nathalia Kelly de Luchessi, Andre Ducati Silbiger, Vivian Nogueira
Palavras-chave:	COVID-19;SARS-CoV-2 infection;Retinol;Vitamin A;Long COVID
Data do documento:	2023
Editor:	Nutrients
Referência:	CARVALHO, Maria Clara da Cruz; ARAÚJO, Júlia Kaline Carvalho Pereira; SILVA, Ana Gabriella Costa Lemos da; SILVA, Nayara Sousa da; Araújo, Nathalia Kelly de; LUCHESSI, Andre Ducati; RIBEIRO, Karla Danielly da Silva; SILBIGER, Vivian.Nogueira. Retinol Levels and Severity of Patients with COVID-19. Nutrients, 2023, 15, 4642. DOI: https://doi.org/10.3390/nu15214642
Resumo:	The new coronavirus infection represents a serious threat to global health and economies. In this sense, it is paramount to know the nutritional factors that may be related to the prognosis of the disease. Evidence shows that vitamin A may play an important preventive and therapeutic role in supporting respiratory infections as in COVID-19. The aim of our study was to evaluate the association of vitamin A (retinol) status with the prognosis of the disease. A case–control study from a cohort study was conducted in Brazil between May and October 2020. The study population was chosen by convenience, consisting of participants diagnosed with COVID-19. Recruitment was carried out using different approaches, including through dissemination on social media and in four hospitals in the city of Natal/RN, Brazil, recruiting participants from the COVID-19 ward and hospitalized participants who tested positive for the disease. The participants were allocated into two groups according to severity, with a group of mild (n = 88) or critical (n = 106) patients and compared to a control group (selected before the pandemic, n = 46). The extraction of retinol serum was performed and analyzed using the high-performance liquid chromatography method (HPLC). The retinol level was calculated in mmol/L, and levels below 0.7 μmol/L (20 µg/dL) were considered to be a vitamin A deficiency. Our findings suggest that the participants with mild and critical COVID-19 had lower retinol levels compared to the healthy controls (p = 0.03). In addition, milder cases of COVID-19 were associated with increased symptoms and prolonged symptoms after 90 days since the beginning of infection. However, the survival analysis showed no association with higher cases of death among participants with vitamin A deficiency (p = 0.509). More studies are needed to understand how nutritional status, including vitamin A levels, can influence prognosis and is a risk factor for the development of long COVID syndrome.
URI:	https://repositorio.ufrn.br/handle/123456789/60690
ISSN:	2072-6643
Aparece nas coleções:	CCS - DNUT - Artigos publicados em periódicos

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