Safety and bioactive potential of nanoparticles containing Cantaloupe melon (Cucumis melo L.) carotenoids in an experimental model of chronic inflammation

Página do item simplificado Estatísticas
dc.contributor.authorMorais, Ana Heloneida de Araújo
dc.contributor.authorMedeiros, Isaiane
dc.contributor.authorOliveira, Grazielle Louise Ribeiro de
dc.contributor.authorQueiroz, Jaluza Luana Carvalho de
dc.contributor.authorGomes, Camila de Carvalho
dc.contributor.authorCarvalho, Fabiana Maria Coimbra de
dc.contributor.authorLima, Maíra Conceição Jerônimo de Souza
dc.contributor.authorSerquiz, Alexandre Coelho
dc.contributor.authorSantos, Pedro Paulo de Andrade
dc.contributor.authorCamillo, Christina da Silva
dc.contributor.authorMaciel, Bruna Leal Lima
dc.contributor.authorPassos, Thaís Souza
dc.contributor.authorIDhttps://orcid.org/0000-0002-6460-911Xpt_BR
dc.date.accessioned2023-08-28T21:26:46Z
dc.date.available2023-08-28T21:26:46Z
dc.date.issued2020
dc.description.resumoThe safety and bioactive potential of crude carotenoid extract from Cantaloupe melon nanoencapsulated in porcine gelatin (EPG) were evaluated in a chronic inflammatory experimental model. Animals were fed a high glycemic index and high glycemic load (HGLI) diet for 17 weeks and treated for ten days with 1) HGLI diet, 2) standard diet, 3) HGLI diet + crude carotenoid extract (CE) (12.5 mg/kg), and 4) HGLI diet + EPG (50 mg/kg). General toxicity signals were investigated, considering body weight, food intake, hematological, biochemical parameters, relative weight, morphology, and histopathology of organs. The biochemical parameters indicated the low toxicity of EPG. Acute hepatitis was observed in animals' livers, but CE and EPG groups presented improved tissue appearance. Chronic enteritis was observed in animals, with villi and intestinal glands preservation in the EPG group. The results suggest the safety and the bioactive effect of EPG, possibly related to its anti-inflammatory potentialpt_BR
dc.identifier.citationMEDEIROS, Isaiane et al. Safety and bioactive potential of nanoparticles containing Cantaloupe melon (Cucumis melo L.) carotenoids in an experimental model of chronic inflammation. Biotechnology Reports, v. 28, p. e00567, 2020.Disponível em: https://linkinghub.elsevier.com/retrieve/pii/S2215017X20308298. Acesso em: 5 jul. 2023.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.btre.2020.e00567
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/54626
dc.languageenpt_BR
dc.publisherElsevierpt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectβ-carotenept_BR
dc.subjectcurcubitaceaept_BR
dc.subjectnanotechnologypt_BR
dc.subjecttoxicitypt_BR
dc.subjectobesitypt_BR
dc.titleSafety and bioactive potential of nanoparticles containing Cantaloupe melon (Cucumis melo L.) carotenoids in an experimental model of chronic inflammationpt_BR
dc.typearticlept_BR

Arquivos

Pacote Original

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
Safetyandbioactivepotential_Medeiros_2020.pdf
Tamanho:
6.14 MB
Formato:
Adobe Portable Document Format
Nenhuma Miniatura disponível
Baixar

Licença do Pacote

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.45 KB
Formato:
Item-specific license agreed upon to submission
Nenhuma Miniatura disponível
Baixar

Coleções

CCS - DNUT - Artigos publicados em periódicos
Repositório Institucional - UFRN Campus Universitário Lagoa NovaCEP 59078-970 Caixa postal 1524 Natal/RN - BrasilUniversidade Federal do Rio Grande do Norte© Copyright 2025. Todos os direitos reservados.
Contato+55 (84) 3342-2260 - R232Setor de Repositórios Digitaisrepositorio@bczm.ufrn.br
DSpaceIBICT
OasisBR
LAReferencia
Customizado pela CAT - BCZM