Association between insulin-like growth factor-I levels and the disease progression and anemia in visceral leishmaniasis

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dc.contributor.authorMaciel, Bruna Leal Lima
dc.contributor.authorPinho, Flaviane Alves de
dc.contributor.authorVendrame, Célia Maria Vieira
dc.contributor.authorSilva, Lucilene dos Santos
dc.contributor.authorMiyashiro, Samantha Ive
dc.contributor.authorJerônimo, Selma Maria Bezerra
dc.contributor.authorGoto, Hiro
dc.date.accessioned2024-02-28T19:59:52Z
dc.date.available2024-02-28T19:59:52Z
dc.date.issued2019-04
dc.description.resumoWe analyzed the association between insulin-like growth factor-I (IGF-I) and the pathogenesis of anemia during active visceral leishmaniasis (VL). Serum levels of IGF-I, IGF-binding protein 3 (IGFBP3), and cytokines were measured in samples from individuals with active VL and cured VL, asymptomatic Leishmania-infected, and noninfected individuals. Then, we extended our analysis to VL dogs to evaluate hematimetric parameters, bone marrow alterations, and cytokine and IGF-I expression. We identified a positive correlation between lower IGF-I and IGFBP3 levels in active VL patients and lower hemoglobin levels. In infected dogs, there was a positive correlation between lower IGF-I expression in the bone marrow and lower peripheral blood hematocrit and hemoglobin levels. There was no correlation between decreased IGF-I level/expression and any measured cytokine serum levels in either host. The data suggest that low IGF-I expression is associated with pathogenesis of anemia in active VL, primarily in severe cases, by mechanisms other than alterations in cytokine productionpt_BR
dc.identifier.citationPINHO, Flaviane Alves de; VENDRAME, Célia Maria Vieira; MACIEL, Bruna Leal Lima; SILVA, Lucilene dos Santos; MIYASHIRO, Samantha Ive; JERÔNIMO, Selma Maria Bezerra; GOTO, Hiro. Association between insulin-like growth factor-I levels and the disease progression and anemia in visceral leishmaniasis. The American Journal of Tropical Medicine And Hygiene, [S.l.], v. 100, n. 4, p. 808-815, 3 abr. 2019. DOI: 10.4269/ajtmh.17-0982. Disponível em: https://www.ajtmh.org/view/journals/tpmd/100/4/article-p808.xml. Acesso em: 6 fev. 2024.pt_BR
dc.identifier.doihttp://dx.doi.org/10.4269/ajtmh.17-0982
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/57712
dc.languageenpt_BR
dc.publisherAmerican Journal of Tropical Medicine and Hygienept_BR
dc.subjectInsulin-like growth factor-Ipt_BR
dc.subjectVisceral leishmaniasispt_BR
dc.subjectAnemiapt_BR
dc.subjectPathogenesispt_BR
dc.titleAssociation between insulin-like growth factor-I levels and the disease progression and anemia in visceral leishmaniasispt_BR
dc.typearticlept_BR

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