Effect of a one-week balanced diet on expression of genes related to zinc metabolism and inflammation in type 2 diabetic patients

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dc.contributor.authorVale, Sancha Helena de Lima
dc.contributor.authorLais, Lucia Leite
dc.contributor.authorXavier, Camila Alves
dc.contributor.authorSilva, Alfredo de Araujo
dc.contributor.authorAydemir, Tolunay Beker
dc.contributor.authorCousins, Robert J
dc.contributor.authorIDhttps://orcid.org/0000-0002-0972-1678
dc.contributor.authorIDhttps://orcid.org/0000-0002-8061-7048
dc.date.accessioned2025-06-27T18:57:42Z
dc.date.available2025-06-27T18:57:42Z
dc.date.issued2016-01-29
dc.description.resumoTo evaluate the effect of diet on metabolic control and zinc metabolism in patients with type 2 diabetes mellitus (T2DM). One-week balanced diet was provided to 10 Brazilians patients with T2DM. Nutritional assessment, laboratorial parameters and expression of zinc transporter and inflammatory genes in peripheral blood mononuclear cells (PBMC) were performed. Healthy non-diabetic subjects of the same demographic were recruited to provide baseline data. Diabetic patients had higher body mass index and greater fasting plasma glucose, plasma tumor necrosis factor α (TNFα) and plasma interleukin 6 (IL6) levels compared with healthy subjects. In addition, the expression of transporters 4 (ZnT4) mRNA was lower and IL6 mRNA was higher in PBMC of these diabetic patients than in healthy subject. One week after a balanced diet was provided, fasting plasma glucose decreased significantly as did TNFα, IL6 and Metallothionein 1 (MT1) mRNAs. No change was observed in zinc transporter expression in PBMC after the dietary intervention. A healthy eating pattern maintained for one week was able to improve metabolic control of diabetic patients by lowering fasting plasma glucose. This metabolic control may be related to down-regulation of zinc-related transcripts from PBMCs, as TNFα, IL6 and MT1 mRNA
dc.identifier.citationLAIS, Lucia Leite; VALE, Sancha Helena de Lima; XAVIER, Camila Alves; SILVA, Alfredo de Araujo; AYDEMIR, Tolunay Beker; COUSINS, Robert J.. Effect of a one-week balanced diet on expression of genes related to zinc metabolism and inflammation in type 2 diabetic patients. Clinical Nutrition Research, [S.l.], v. 5, n. 1, p. 26-32, 29 jan. 2016. DOI: 10.7762/cnr.2016.5.1.26. Disponível em: https://e-cnr.org/DOIx.php?id=10.7762/cnr.2016.5.1.26. Acesso em: 15 jul. 2024.
dc.identifier.otherhttp://dx.doi.org/10.7762/cnr.2016.5.1.26
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/64058
dc.language.isoen_US
dc.publisherClinical Nutrition Research
dc.rightsAttribution-NonCommercial 3.0 Brazilen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/br/
dc.subjectDiet
dc.subjectType 2 diabetes mellitus
dc.subjectZinc
dc.subjectNutrigenomics
dc.titleEffect of a one-week balanced diet on expression of genes related to zinc metabolism and inflammation in type 2 diabetic patients
dc.typearticle

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