Medial septal dysfunction by ABeta-induced KCNQ channel-block in glutamatergic neurons
| dc.contributor.author | Leão, Richardson Naves | |
| dc.contributor.author | Luis V. Colom | |
| dc.contributor.author | Lotta Borgius | |
| dc.contributor.author | Ole Kiehn | |
| dc.contributor.author | André Fisahn | |
| dc.date.accessioned | 2017-05-31T12:11:21Z | |
| dc.date.available | 2017-05-31T12:11:21Z | |
| dc.date.issued | 2011-07 | |
| dc.description.resumo | Amyloid (A ) peptides play a central role in the pathophysiology of Alzheimer’s disease (AD). The cellular mechanisms underlying A toxicity, however, are poorly understood. Here we show that A 25-35 and A 1-40 acutely and differentially affect the characteristics of 3 classes of medial septum (MS) neurons in mice. In glutamatergic neurons A increases firing frequency and blocks the A- and the M-current (IA and IM, respectively). While the IA block is similar in other MS neuron classes, the block of IM is specific to glutamatergic neurons. IM block and a simulated A block mimic the A -induced increase in spontaneous firing in glutamatergic neurons. Calcium imaging shows that under control conditions glutamatergic neurons rarely fire while nonglutamatergic neurons fire coherently at theta frequencies. A increases the firing rate of glutamatergic neurons while nonglutamatergic neurons lose theta firing coherence. Our results demonstrate that A -induced dysfunction of glutamatergic neurons via IM decrease diminishes MS rhythmicity, which may negatively affect hippocampal rhythmogenesis and underlie the memory loss observed in Alzheimer’s disease. | pt_BR |
| dc.identifier.issn | 0197-4580 | |
| dc.identifier.uri | https://repositorio.ufrn.br/jspui/handle/123456789/23258 | |
| dc.language | eng | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.subject | Amyloid Beta peptide | pt_BR |
| dc.subject | Medial septum | pt_BR |
| dc.subject | Theta oscillations | pt_BR |
| dc.subject | Glutamatergic neurons | pt_BR |
| dc.subject | Cholinergic neurons | pt_BR |
| dc.subject | GABAergic neurons | pt_BR |
| dc.subject | M-current | pt_BR |
| dc.subject | A-current | pt_BR |
| dc.title | Medial septal dysfunction by ABeta-induced KCNQ channel-block in glutamatergic neurons | pt_BR |
| dc.type | article | pt_BR |
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