Production of recombinant 503 antigen of Leishmania infantum chagasi using cultivation in batch and fed-batch

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dc.contributor.authorSantos, Everaldo Silvino dos
dc.contributor.authorVaz, Michelle Rossana Ferreira
dc.contributor.authorSousa Junior, Francisco Canindé de
dc.contributor.authorPadilha, Carlos Eduardo de Araújo
dc.contributor.authorMartins, Daniella Regina Arantes
dc.contributor.authorMacedo, Gorete Ribeiro
dc.date.accessioned2021-05-21T00:05:01Z
dc.date.available2021-05-21T00:05:01Z
dc.date.issued2014-10-10
dc.description.resumoVisceral leishmaniasis is an infecto-parasitarian disease caused by obligatory intracellular protozoa belonging to the genus Leishmania, and might be lethal since there is no precocious diagnosis and proper treatment. Despite the considerable effort, there is no effective and safe vaccine for human use [1]. Genetically modified micro-organisms are used industrially in general for production of hormone, antibiotics and proteins. In the production of heterologous molecules, both the expression and the production step are important [2]. Therefore, the study of cultivation conditions in bioreactor plays an important role for the process viability of batch and fed-batch [3]. Thus, the aim of this work was to study strategies for production of the 503 antigen of Leishmania infantum chagasi using cultivation in batch and fed-batchpt_BR
dc.identifier.citationVAZ, Michelle Rossana Ferreira; SOUSA JUNIOR, Francisco Canindé de; PADILHA, Carlos Eduardo de Araújo; MARTINS, Daniella Regina Arantes; SANTOS, Everaldo Silvino; MACEDO, Gorete Ribeiro. Production of recombinant 503 antigen of Leishmania infantum chagasi using cultivation in batch and fed-batch. Bmc Proceedings, [S.L.], v. 8, n. 4, out. 2014. Disponível em: https://bmcproc.biomedcentral.com/articles/10.1186/1753-6561-8-S4-P186. Acesso em: 08 abr 2021. http://dx.doi.org/10.1186/1753-6561-8-s4-p186.pt_BR
dc.identifier.doi10.1186/1753-6561-8-S4-P186
dc.identifier.issn1753-6561
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/32541
dc.languageenpt_BR
dc.publisherBMC Proceedingspt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectRecombinant Proteinpt_BR
dc.subjectLactosept_BR
dc.subjectVisceral Leishmaniasispt_BR
dc.subjectHigh Cell Densitypt_BR
dc.subjectLeishmaniasispt_BR
dc.titleProduction of recombinant 503 antigen of Leishmania infantum chagasi using cultivation in batch and fed-batchpt_BR
dc.typearticlept_BR

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