Sleep disrupts complex spiking dynamics in the neocortex and hippocampus

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dc.contributor.authorGonzález, Joaquín
dc.contributor.authorCavelli, Matias
dc.contributor.authorTort, Adriano Bretanha Lopes
dc.contributor.authorTorterolo, Pablo
dc.contributor.authorRubido, Nicolás
dc.date.accessioned2023-10-11T17:30:20Z
dc.date.available2023-10-11T17:30:20Z
dc.date.issued2023-08
dc.description.resumoNeuronal interactions give rise to complex dynamics in cortical networks, often described in terms of the diversity of activity patterns observed in a neural signal. Interestingly, the complexity of spontaneous electroencephalographic signals decreases during slow-wave sleep (SWS); however, the underlying neural mechanisms remain elusive. Here, we analyse in-vivo recordings from neocortical and hippocampal neuronal populations in rats and show that the complexity decrease is due to the emergence of synchronous neuronal DOWN states. Namely, we find that DOWN states during SWS force the population activity to be more recurrent, deterministic, and less random than during REM sleep or wakefulness, which, in turn, leads to less complex field recordings. Importantly, when we exclude DOWN states from the analysis, the recordings during wakefulness and sleep become indistinguishable: the spiking activity in all the states collapses to a common scaling. We complement these results by implementing a critical branching model of the cortex, which shows that inducing DOWN states to only a percentage of neurons is enough to generate a decrease in complexity that replicates SWSpt_BR
dc.identifier.citationGONZÁLEZ, Joaquín; CAVELLI, Matias; TORT, Adriano B. L.; TORTEROLO, Pablo; RUBIDO, Nicolás. Sleep disrupts complex spiking dynamics in the neocortex and hippocampus. Plos One, [S. l.], v. 18, n. 8, p. e0290146, ago. 2023. Doi: http://dx.doi.org/10.1371/journal.pone.0290146. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0290146. Acesso em: 11 out. 2023pt_BR
dc.identifier.doi10.1371/journal.pone.0290146
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/54971
dc.languageenpt_BR
dc.publisherPublic Library of Science (PLoS)pt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectSleep - Neocortexpt_BR
dc.subjectSleep - Hippocampuspt_BR
dc.subjectSpontaneous electroencephalographic signals - Slow-wave sleep (SWS)pt_BR
dc.subjectNeuronal DOWN statespt_BR
dc.subjectNeuronal modellingpt_BR
dc.subjectIn-vivo neuronal populationspt_BR
dc.titleSleep disrupts complex spiking dynamics in the neocortex and hippocampuspt_BR
dc.typearticlept_BR

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