Long-term decrease in immediate early gene expression after electroconvulsive seizures

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dc.contributor.authorCalais, Julien Braga
dc.contributor.authorValvassori, Samira S.
dc.contributor.authorResende, Wilson R.
dc.contributor.authorFeier, Gustavo
dc.contributor.authorAthie, Maria Carolina Pedro
dc.contributor.authorRibeiro, Sidarta Tollendal Gomes
dc.contributor.authorGattaz, Wagner Farid
dc.contributor.authorQuevedo, João
dc.contributor.authorOjopi, Elida Benquique
dc.date.accessioned2017-05-31T11:32:54Z
dc.date.available2017-05-31T11:32:54Z
dc.date.issued2012-08-09
dc.description.resumoElectroconvulsive therapy (ECT) is a wellestablished psychiatric treatment for severe depression. Despite its clinical utility, post-ECT memory deficits are a common side effect. Neuronal plasticity and memory consolidation are intimately related to the expression of immediate early genes (IEG), such as Egr1, Fos and Arc. Changes in IEG activation have been postulated to underlie long-term neuronal adaptations following electroconvulsive seizures (ECS), an animal model of ECT. To test this hypothesis, we used real-time PCR to examine the effect of acute and chronic ECS (8 sessions, one every other day) on the long-term ([24 h) expression of IEG Egr1, Fos and Arc in the hippocampus, a brain region implicated both in the pathophysiology of depression as well as in memory function. We observed a transient increase in Egr1 and Fos expression immediately after ECS, followed by a long-term decrease of IEGlevels after both acute and chronic ECS.Aseparate group of animals, submitted to the same chronic ECS protocol and then subjected to open field or passive avoidance tasks, confirmed robust memory deficits 2 weeks after the last chronic ECS. The possible role of IEG downregulation on long-term learning deficits observed following ECS are discussed.pt_BR
dc.identifier.issn0300-9564
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/23255
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectArcpt_BR
dc.subjectEgr1pt_BR
dc.subjectElectroconvulsive seizurespt_BR
dc.subjectFospt_BR
dc.subjectMemorypt_BR
dc.titleLong-term decrease in immediate early gene expression after electroconvulsive seizurespt_BR
dc.typearticlept_BR

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