Trypsin inhibitor from tamarindus indica L. seeds reduces weight gain and food consumption and increases plasmatic cholecystokinin levels

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dc.contributor.authorMaciel, Bruna Leal Lima
dc.contributor.authorRibeiro, Joycellane Alline do Nascimento Campos
dc.contributor.authorSerquiz, Alexandre Coelho
dc.contributor.authorSilva, Priscila Fabíola dos Santos
dc.contributor.authorBarbalho, Patrícia Batista Barra Medeiros
dc.contributor.authorSampaio, Tarcísio Bruno Montenegro
dc.contributor.authorAraújo, Raimundo Fernandes de
dc.contributor.authorOliveira, Adeliana Silva de
dc.contributor.authorMachado, Richele Janaina Araújo
dc.contributor.authorUchôa, Adriana Ferreira
dc.contributor.authorSantos, Elizeu Antunes dos
dc.contributor.authorMorais, Ana Heloneida de Araújo
dc.date.accessioned2024-02-27T19:45:19Z
dc.date.available2024-02-27T19:45:19Z
dc.date.issued2015-02
dc.description.resumoObjectives: Seeds are excellent sources of proteinase inhibitors, some of which may have satietogenic and slimming actions. We evaluated the effect of a trypsin inhibitor from Tamarindus indica L. seeds on weight gain, food consumption and cholecystokinin levels in Wistar rats. Methods: A trypsin inhibitor from Tamarindus was isolated using ammonium sulfate (30–60%) following precipitation with acetone and was further isolated with Trypsin-Sepharose affinity chromatography. Analyses were conducted to assess the in vivo digestibility, food intake, body weight evolution and cholecystokinin levels in Wistar rats. Histological analyses of organs and biochemical analyses of sera were performed. Results: The trypsin inhibitor from Tamarindus reduced food consumption, thereby reducing weight gain. The in vivo true digestibility was not significantly different between the control and Tamarindus trypsin inhibitortreated groups. The trypsin inhibitor from Tamarindus did not cause alterations in biochemical parameters or liver, stomach, intestine or pancreas histology. Rats treated with the trypsin inhibitor showed significantly elevated cholecystokinin levels compared with animals receiving casein or water. Conclusion: The results indicate that the isolated trypsin inhibitor from Tamarindus reduces weight gain by reducing food consumption, an effect that may be mediated by increased cholecystokinin. Thus, the potential use of this trypsin inhibitor in obesity prevention and/or treatment should be evaluatedpt_BR
dc.identifier.citationRIBEIRO, Joycellane Alline do Nascimento Campos; SERQUIZ, Alexandre Coelho; SILVA, Priscila Fabíola dos Santos; BARBOSA, Patrícia Batista Barra Medeiros; SAMPAIO, Tarcísio Bruno Montenegro; ARAÚJO, Raimundo Fernandes de; OLIVEIRA, Adeliana Silva de; MACHADO, Richele Janaina Araújo; MACIEL, Bruna Leal Lima; UCHÔA, Adriana Ferreira; SANTOS, Elizeu Antunes dos; MORAIS, Ana Heloneida de Araújo. Trypsin inhibitor from tamarindus indica L. seeds reduces weight gain and food consumption and increases plasmatic cholecystokinin levels. Clinics, [S.l.], v. 70, n. 2, p. 136-143, fev. 2015. Elsevier BV. http://dx.doi.org/10.6061/clinics/2015(02)11. Disponível em: https://www.sciencedirect.com/science/article/pii/S1807593222008079?via%3Dihub. Acesso em: 05 fev. 2024.pt_BR
dc.identifier.doihttp://dx.doi.org/10.6061/clinics/2015(02)11
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/57694
dc.languageenpt_BR
dc.publisherClinicspt_BR
dc.rightsAttribution-NonCommercial 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/br/*
dc.subjectTamarindpt_BR
dc.subjectSatietypt_BR
dc.subjectSlimmingpt_BR
dc.subjectObesitypt_BR
dc.subjectCCKpt_BR
dc.titleTrypsin inhibitor from tamarindus indica L. seeds reduces weight gain and food consumption and increases plasmatic cholecystokinin levelspt_BR
dc.typearticlept_BR

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