Hippocampal Respiration-Driven Rhythm Distinct from Theta Oscillations in Awake Mice

Chi, Vivan Nguyen; Muller, Carola; Wolfenstetter, Thérèse; Yanovsky, Yevgenij; Draguhn, Andreas; Tort, Adriano Bretanha Lopes; Brankack, Jurij

Hippocampal Respiration-Driven Rhythm Distinct from Theta Oscillations in Awake Mice

Página do item simplificado Estatísticas

dc.contributor.author	Chi, Vivan Nguyen
dc.contributor.author	Muller, Carola
dc.contributor.author	Wolfenstetter, Thérèse
dc.contributor.author	Yanovsky, Yevgenij
dc.contributor.author	Draguhn, Andreas
dc.contributor.author	Tort, Adriano Bretanha Lopes
dc.contributor.author	Brankack, Jurij
dc.date.accessioned	2017-05-24T14:28:44Z
dc.date.available	2017-05-24T14:28:44Z
dc.date.issued	2016
dc.description.resumo	We have recently described a slow oscillation in the hippocampus of urethane-anesthetized mice, which couples to nasal respiration and is clearly distinct from co-occurring theta oscillations. Here we set out to investigate whether such type of patterned network activity, which we named “hippocampal respiration rhythm” (HRR), also occurs in awake mice. In freely moving mice, instantaneous respiration rate is extremely variable, and respiration is superimposed by bouts of sniffing. To reduce this variability, we clamped the behavior of the animal to either awake immobility or treadmill running by using a head-fixed setup while simultaneously recording respiration and field potentials from the olfactory bulb (OB) and hippocampus. Head-fixed animals often exhibited long periods of steady respiration rate during either immobility or running, which allowed for spectral and coherence analyses with a sufficient frequency resolution to sort apart respiration and theta activities. We could thus demonstrate the existence of HRR in awake animals, namely, a respiration-entrained slow rhythm with highest amplitude at the dentate gyrus. HRR was most prominent during immobility and running with respiration rates slower than theta oscillations. Nevertheless, HRR could also be faster than theta. Discharges of juxtacellularly recorded cells in CA1 and dentate gyrus were modulated by HRR and theta oscillations. Granger directionality analysis revealed that HRR is caused by the OB and that theta oscillations in OB are caused by the hippocampus. Our results suggest that respiration-coupled oscillations aid the exchange of information between olfactory and memory networks.	pt_BR
dc.identifier.doi	10.1523/JNEUROSCI.2848-15.2016
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/23064
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	hippocampus	pt_BR
dc.subject	mouse	pt_BR
dc.subject	olfactory bulb	pt_BR
dc.subject	oscillation	pt_BR
dc.subject	respiration	pt_BR
dc.subject	theta rhythm	pt_BR
dc.title	Hippocampal Respiration-Driven Rhythm Distinct from Theta Oscillations in Awake Mice	pt_BR
dc.type	article	pt_BR