Unraveling the protective genetic architecture of COVID-19 in the Brazilian Amazon

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dc.contributor.authorBarros, Maria Clara
dc.contributor.authorSouza, Jorge Estefano Santana de
dc.contributor.authorGomes, Daniel Henrique Ferreira
dc.contributor.authorPinho, Catarina Torres
dc.contributor.authorSilva, Caio Santos
dc.contributor.authorSilva, Cintia Helena Braga da
dc.contributor.authorCavalcante, Giovanna Chaves
dc.contributor.authorMagalhães, Leandro
dc.contributor.authorPinheiro, Jhully Azevedo dos Santos
dc.contributor.authorQuaresma, Juarez Antônio Simões
dc.contributor.authorFalcão, Luiz Fábio Magno
dc.contributor.authorCosta, Patrícia Fagundes
dc.contributor.authorSalgado, Cláudio Guedes
dc.contributor.authorCarneiro, Thiago Xavier
dc.contributor.authorBurbano, Rommel Rodrigues
dc.contributor.authorVieira, José Ricardo dos Santos
dc.contributor.authorSantos, Sidney
dc.contributor.authorSouza, Giordano Bruno Soares
dc.contributor.authorSouza, Sandro José de
dc.contributor.authorSantos, Andrea Kely Campos Ribeiro dos
dc.date.accessioned2025-01-08T13:34:42Z
dc.date.available2025-01-08T13:34:42Z
dc.date.issued2024-11
dc.description.resumoDespite all the efforts acquired in four years of the COVID-19 pandemic, the path to a full understanding of the biological mechanisms involved in this disease remains complex. This is partly due to a combination of factors, including the inherent characteristics of the infection, socio-environmental elements, and the variations observed within both the viral and the human genomes. Thus, this study aimed to investigate the correlation between genetic host factors and the severity of COVID-19. We conducted whole exome sequencing (WES) of 124 patients, categorized into severe and non-severe groups. From the whole exome sequencing (WES) association analysis, four variants (rs1770731 in CRYBG1, rs7221209 in DNAH17, rs3826295 in DGKE, and rs7913626 in CFAP46) were identified as potentially linked to a protective effect against the clinical severity of COVID-19, which may explain the less severe impact of COVID-19 on the Northern Region. Our findings underscore the importance of carrying out more genomic studies in populations living in the Amazon, one of the most diverse from the point of view of the presence of rare and specific alleles. To our knowledge, this is the first WES study of admixed individuals from the Brazilian Amazon to investigate genomic variants associated with the clinical severity of COVID-19pt_BR
dc.identifier.citationBARROS, Maria Clara; SOUZA, Jorge Estefano Santana de; GOMES, Daniel Henrique F.; PINHO, Catarina Torres; SILVA, Caio S.; BRAGA-DA-SILVA, Cíntia; CAVALCANTE, Giovanna C.; MAGALHÃES, Leandro; AZEVEDO-PINHEIRO, Jhully; QUARESMA, Juarez Antônio Simões; FALCÃO, Luiz Fábio Magno; COSTA, Patrícia Fagundes; SALGADO, Cláudio Guedes; CARNEIRO, Thiago Xavier; BURBANO, Rommel Rodrigues; VIEIRA, José Ricardo dos Santos; SANTOS, Sidney; SOARES-SOUZA, Giordano Bruno; SOUZA, Sandro José de; RIBEIRO-DOS-SANTOS, Andrea. Unraveling the protective genetic architecture of COVID-19 in the Brazilian Amazon. Scientific Reports, [S. l.], v. 14, n. 1, p. 27332, nov. 2024. Doi: http://dx.doi.org/10.1038/s41598-024-78170-3. Disponível em: https://www.nature.com/articles/s41598-024-78170-3. Acesso em: 07 jan. 2025pt_BR
dc.identifier.doi10.1038/s41598-024-78170-3
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/61048
dc.languageenpt_BR
dc.publisherSpringer Science and Business Media LLCpt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectCOVID-19 - Brazilian Amazonpt_BR
dc.subjectCOVID-19 - Clinical severitypt_BR
dc.subjectSARS-CoV-2pt_BR
dc.subjectWhole Exome Sequencing (WES)pt_BR
dc.subjectGenomic studies - Amazonian populationspt_BR
dc.titleUnraveling the protective genetic architecture of COVID-19 in the Brazilian Amazonpt_BR
dc.typearticlept_BR

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