Acute effects of ayahuasca in a juvenile non-human primate model of depression

Silva, Flávia S. da; Silva, Erick A. S.; Sousa Jr., Geovan M. de; Maia-de-Oliveira, João P.; Soares-Rachetti, Vanessa de Paula; Araújo, Dráulio Barros de; Sousa, Maria Bernardete Cordeiro de; Lobão-Soares, Bruno; Hallak, Jaime; Galvão-Coelho, Nicole L.

Acute effects of ayahuasca in a juvenile non-human primate model of depression

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dc.contributor.author	Silva, Flávia S. da
dc.contributor.author	Silva, Erick A. S.
dc.contributor.author	Sousa Jr., Geovan M. de
dc.contributor.author	Maia-de-Oliveira, João P.
dc.contributor.author	Soares-Rachetti, Vanessa de Paula
dc.contributor.author	Araújo, Dráulio Barros de
dc.contributor.author	Sousa, Maria Bernardete Cordeiro de
dc.contributor.author	Lobão-Soares, Bruno
dc.contributor.author	Hallak, Jaime
dc.contributor.author	Galvão-Coelho, Nicole L.
dc.date.accessioned	2019-01-08T12:36:09Z
dc.date.available	2019-01-08T12:36:09Z
dc.date.issued	2018-11-08
dc.description.resumo	Objective: The incidence rate of major depression in adolescents reaches approximately 14%. This disorder is usually recurrent, without remission of symptoms even after pharmacological treatment, and persists throughout adult life. Since the effects of antidepressants take approximately 2 weeks to begin, new pharmacological therapies are under continuous exploration. Recent evidence suggests that psychedelics could produce rapid antidepressant effects. In this study, we evaluated the potential antidepressant effects of ayahuasca in a juvenile non-human primate model of depression. Methods: While living with their families, juvenile marmosets (8 males; 7 females) were observed on alternate days for four weeks during a baseline phase. This was followed by 8 weeks of an induced depressive state protocol, the social isolated context (IC), in which the animals were monitored in the first and last weeks. Subsequently, five males and four females were randomly selected for treatment, first with a single administration of saline vehicle (1.67 mL/300 g of body weight, via gavage), followed by a single dose of ayahuasca (1.67 mL/300 g of body weight, via gavage). Both phases lasted 1 week and the animals were monitored daily. A third week of sampling was called the tardive-pharmacological effects phase. In all phases the marmosets were assessed for behavior, fecal cortisol levels, and body weight. Results: After IC, the animals presented typical hypocortisolemia, but cortisol recovered to baseline levels 24 h after an acute dose of ayahuasca; this recovery was not observed in vehicle-treated animals. Additionally, in males, ayahuasca, but not the vehicle, reduced scratching, a stereotypic behavior, and increased feeding. Ayahuasca treatment also improved body weight to baseline levels in both sexes. The ayahuasca-induced behavioral response had long-term effects (14 days). Thus, in this translational juvenile animal model of depression, ayahuasca presented beneficial effects. Conclusions: These results can contribute to the validation of ayahuasca as an antidepressant drug and encourage new studies on psychedelic drugs as a tool for treating mood disorders, including for adolescents with early-onset depression.	pt_BR
dc.identifier.citation	SILVA, F. S. et al. Acute effects of ayahuasca in a juvenile non-human primate model of depression. Braz. J. Psychiatry, São Paulo, 2018. doi: http://dx.doi.org/10.1590/1516-4446-2018-0140.	pt_BR
dc.identifier.doi	http://dx.doi.org/10.1590/1516-4446-2018-0140
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/26423
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	Translational animal model	pt_BR
dc.subject	non-human primate	pt_BR
dc.subject	common marmoset	pt_BR
dc.subject	marmoset	pt_BR
dc.subject	cortisol	pt_BR
dc.subject	early-age depression	pt_BR
dc.subject	psychedelic drugs	pt_BR
dc.title	Acute effects of ayahuasca in a juvenile non-human primate model of depression	pt_BR
dc.type	article	pt_BR