Safety and potential functionality of nanoparticles loaded with a trypsin inhibitor isolated from tamarind seeds

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dc.contributor.authorMorais, Ana Heloneida Araújo
dc.contributor.authorCosta, Rafael Oliveira de Araújo
dc.contributor.authorMatias, Lídia Leonize Rodrigues
dc.contributor.authorPassos, Thaís Souza
dc.contributor.authorQueiroz, Jaluza Luana Carvalho de
dc.contributor.authorCarvalho, Fabiana Maria Coimbra de
dc.contributor.authorMaciel, Bruna Leal Lima
dc.contributor.authorUchôa, Adriana Ferreira
dc.contributor.authorAmado, Isabel Rodríguez
dc.contributor.authorGonçalves, Catarina
dc.contributor.authorPastrana, Lorenzo
dc.contributor.authorIDhttps://orcid.org/0000-0002-6460-911Xpt_BR
dc.date.accessioned2023-08-28T22:26:29Z
dc.date.available2023-08-28T22:26:29Z
dc.date.issued2020
dc.description.resumoThe trypsin inhibitor isolated from tamarind seeds(TTI) presentssatietogenic and anti-inflammatory effects. In the present study, TTI encapsulation by nanoprecipitation in purified chitosan and whey protein isolate (ECW) was performed to maintain TTI’s integrity and protection through the gastrointestinal tract. The interaction between TTI and the encapsulating agents was determined by filtration monitoring the antitrypsin activity. Cytotoxicity was evaluated at different concentrations (0.5, 2.5 and 5.0 mg/mL) in Caco-2 and CCD-18Co cells. Subacute blood toxicity was evaluated in Wistar rats (12.5 mg/kg) for ten days. The particles presented a smooth surface, with 118.00 (17.27) nm of diameter, 0.37 (0.02) of polydispersity index, -38.26 (0.15) mV (neutral pH) of sur face charge, and 95.31 (0.31)% of incorporation efficiency. At neutral pH, there was a strong interaction of the encapsulating agents and TTI, and a gradual release of TTI at pH 3.0. Cell viability (> 70%) evaluation, in vivo biochemical and hepatic parameters of Wistar rats showed the absence of toxic effects of the nanoparticles with TTI. The study showed that TTI nanoparticles are potentially safe and represent a promising formulation for the clinical application of TTI and may become an option as a novel ingredient in foodpt_BR
dc.identifier.citationCOSTA, Rafael Oliveira de Araújo et al. Safety and potential functionality of nanoparticles loaded with a trypsin inhibitor isolated from tamarind seeds. Future Foods, v. 1, p. 100001, 2020. Disponível em: https://www.sciencedirect.com/science/article/pii/S2666833520300010?via%3Dihub. Acesso em: 5 jul.2023.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.fufo.2020.100001
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/54627
dc.languageenpt_BR
dc.publisherElsevierpt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectTamarindus indica L.pt_BR
dc.subjectcytotoxicitypt_BR
dc.subjectCaco-2pt_BR
dc.subjectCCD-18Copt_BR
dc.subjecttoxicitypt_BR
dc.subjectnanoencapsulationpt_BR
dc.subjectbiopolymerpt_BR
dc.titleSafety and potential functionality of nanoparticles loaded with a trypsin inhibitor isolated from tamarind seedspt_BR
dc.typearticlept_BR

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