Effect of a single high dose of vitamin D3 on cytokines, chemokines, and growth factor in patients with moderate to severe COVID-19

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dc.contributor.authorReis, Bruna Zavarize
dc.contributor.authorFernandes, Alan Lins
dc.contributor.authorMurai, Igor Hisashi
dc.contributor.authorSales, Lucas Peixoto
dc.contributor.authorSantos, Mayara Diniz
dc.contributor.authorPinto, Ana Jéssica
dc.contributor.authorGoessler, Karla Fabiana
dc.contributor.authorDuran, Camila da Silva Cendon
dc.contributor.authorSilva, Carla Baleeiro Rodrigues
dc.contributor.authorFranco, André Silva
dc.contributor.authorMacêdo, Marina Barguil
dc.contributor.authorDalmolin, Henrique Helson Herter
dc.contributor.authorBaggio, Janaína
dc.contributor.authorBalbi, Guilherme Guimarães Moreira
dc.contributor.authorAntonangelo, Leila
dc.contributor.authorCaparbo, Valéria de Falco
dc.contributor.authorGualano, Bruno
dc.contributor.authorPereira, Rosa Maria Rodrigues
dc.date.accessioned2024-03-01T21:25:06Z
dc.date.available2024-03-01T21:25:06Z
dc.date.issued2022-03
dc.description.resumoBackground: The modulating effect of vitamin D on cytokine concentrations in severe coronavirus disease 2019 (COVID-19) remains unknown. Objectives: We aimed to investigate the effect of a single high dose of vitamin D3 on cytokines, chemokines, and growth factor in hospitalized patients with moderate to severe COVID-19. Methods: This is a post hoc, ancillary, and exploratory analysis from a multicenter, double-blind, placebo-controlled, randomized clinical trial. Patients with moderate to severe COVID-19 were recruited from 2 hospitals in São Paulo, Brazil. Of 240 randomly assigned patients, 200 were assessed in this study and randomly assigned to receive a single oral dose of 200,000 IU vitamin D3 (n = 101) or placebo (n = 99). The primary outcome was hospital length of stay, which has been published in our previous study. The prespecified secondary outcomes were serum concentrations of IL-1β, IL-6, IL-10, TNF-α, and 25-hydroxyvitamin D. The post hoc exploratory secondary outcomes were IL-4, IL-12p70, IL-17A, IFN-γ , granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-8, IFN-inducible protein-10 (IP-10), macrophage inflammatory protein-1β (MIP-1β), monocyte chemoattractant protein-1 (MCP-1), vascular endothelial growth factor (VEGF), and leukocyte count. Generalized estimating equations for repeated measures, with Bonferroni’s adjustment, were used for testing all outcomes. Results: The study included 200 patients with a mean ± SD age of 55.5 ± 14.3 y and BMI of 32.2 ± 7.1 kg/m2, of which 109 (54.5%) were male. GM-CSF concentrations showed a significant group-by-time interaction effect (P = 0.04), although the betweengroup difference at postintervention after Bonferroni’s adjustment was not significant. No significant effects were observed for the other outcomes. Conclusions: The findings do not support the use of a single dose of 200,000 IU vitamin D3, compared with placebo, for the improvement of cytokines, chemokines, and growth factor in hospitalized patients with moderate to severe COVID-19. This trial was registered at clinicaltrials.gov as NCT04449718. Am J Clin Nutr 2022;115:790–798pt_BR
dc.identifier.citationFERNANDES, Alan Lins; MUIRAI, Igor Hisashi; REIS, Bruna Zavarize; SALES, Lucas Peixoto; SANTOS, Mayara Diniz; PINTO, Ana Jéssica; GOESSLER, Karla Fabiana; DURAN, Camila da Silva Cendon; SILVA, Carla Baleeiro Rodrigues; FRANCO, André Silva; MACÊDO, Marina Barguil; DALMOLIN, Henrique Helson Herter; BAGGIO, Janaína; BALBI, Guilherme Guimarães Moreira; ANTONANGELO, Leila; CAPARBO, Valéria de Falco; GUALANO, Bruno; PEREIRA, Rosa Maria Rodrigues. Effect of a single high dose of vitamin D3 on cytokines, chemokines, and growth factor in patients with moderate to severe COVID-19. The American Journal of Clinical Nutrition, [S.l.], v. 115, n. 3, p. 790-798, mar. 2022. DOI: 10.1093/ajcn/nqab426. Disponível em: https://www.sciencedirect.com/science/article/pii/S0002916522001964?via%3Dihub. Acesso em: 16 fev. 2024.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1093/ajcn/nqab426
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/57728
dc.languageenpt_BR
dc.publisherThe American Journal of Clinical Nutritionpt_BR
dc.subjectImmune responsept_BR
dc.subjectSARS-CoV-2pt_BR
dc.subjectInflammationpt_BR
dc.subjectAcutephase reactantspt_BR
dc.subjectVitamin Dpt_BR
dc.titleEffect of a single high dose of vitamin D3 on cytokines, chemokines, and growth factor in patients with moderate to severe COVID-19pt_BR
dc.typearticlept_BR

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