Emotion regulation effects of Ayahuasca in experienced subjects during implicit aversive stimulation: an fMRI study

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dc.contributor.authorSanchez, Tiago Arruda
dc.contributor.authorRamos, Lucas Rego
dc.contributor.authorAraujo, Felipe
dc.contributor.authorSchenberg, Eduardo Ekman
dc.contributor.authorYonamine, Mauricio
dc.contributor.authorLobo, Isabela
dc.contributor.authorAraujo, Draulio Barros de
dc.contributor.authorLuna, Luis Eduardo
dc.date.accessioned2023-11-24T15:23:10Z
dc.date.available2023-11-24T15:23:10Z
dc.date.issued2023-11
dc.description.resumoEthnopharmacological relevance: Ayahuasca is a beverage used in Amazonian traditional medicine and it has been part of the human experience for millennia as well as other different psychoactive plants. Although Ayahuasca has been proposed as potentially therapeutic as an anxiolytic and antidepressant, whilst no studies have been carried out so far investigating their direct effect on brain emotional processing. Aim of the study: This study aimed to measure the emotional acute effect of Ayahuasca on brain response to implicit aversive stimulation using a face recognition task in functional magnetic resonance imaging (fMRI). Materials and methods: Nineteen male experienced Ayahuasca users participated in this study in two fMRI sessions before and after 50 min of the Ayahuasca ingestion. Subjects were presented with pictures of neutral (A) and aversive (B) (fearful or disgusted) faces from the Pictures of Facial Affect Series. Subjects were instructed to identify the gender of the faces (gender discrimination task) while the emotional content was implicit. Subjective mood states were also evaluated before Ayahuasca intake and after the second fMRI session, using a visual analogue mood scale (VAMS). Results: During the aversive stimuli, the activity in the bilateral amygdala was attenuated by Ayahuasca (qFDR<0.05). Furthermore, in an exploratory analysis of the effects after intake, Ayahuasca enhances the activation bilaterally in the insula, as well as in the right dorsolateral prefrontal cortex (qFDR<0.05). In the psychometric VAMS scale, subjects reported attenuation of both anxiety and mental sedation (p < 0.01) during acute effects. Conclusions: Together, all reported results including neuroimaging, behavioral data and psychometric self-report suggest that Ayahuasca can promote an emotion regulation mechanism in response to aversive stimuli with corresponding improved cognition including reduced anxiety and mental sedationpt_BR
dc.identifier.citationSANCHEZ, Tiago Arruda; RAMOS, Lucas Rego; ARAUJO, Felipe; SCHENBERG, Eduardo Ekman; YONAMINE, Mauricio; LOBO, Isabela; ARAUJO, Draulio Barros de; LUNA, Luis Eduardo. Emotion regulation effects of Ayahuasca in experienced subjects during implicit aversive stimulation: An fmri study. Journal of Ethnopharmacology, [S. l.], p. 117430, nov. 2023. DOI http://dx.doi.org/10.1016/j.jep.2023.117430. Disponível em: https://www.sciencedirect.com/science/article/pii/S0378874123013004?via%3Dihub. Acesso em: 22 nov. 2023.pt_BR
dc.identifier.doi10.1016/j.jep.2023.117430
dc.identifier.issne1872-7573
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/55426
dc.languageenpt_BR
dc.publisherElsevier BVpt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectayahuascapt_BR
dc.subjectbanisteriopsispt_BR
dc.subjectdimethyltryptaminept_BR
dc.subjectN,N-Dimethyltryptaminept_BR
dc.subjectemotionpt_BR
dc.subjectharminept_BR
dc.subjectpsychedelicpt_BR
dc.subjecthallucinogenspt_BR
dc.subjectfMRIpt_BR
dc.subjectmagnetic Resonance Imagingpt_BR
dc.titleEmotion regulation effects of Ayahuasca in experienced subjects during implicit aversive stimulation: an fMRI studypt_BR
dc.typearticlept_BR

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