Molecular profile of variants potentially associated with severe forms of COVID-19 in Amazonian indigenous populations

Página do item simplificado Estatísticas
dc.contributor.authorCoelho, Rita de Cássia Calderaro
dc.contributor.authorMartins, Carlliane Lima e Lins Pinto
dc.contributor.authorPastana, Lucas Favacho
dc.contributor.authorRodrigues, Juliana Carla Gomes
dc.contributor.authorAguiar, Kaio Evandro Cardoso
dc.contributor.authorPaes, Amanda de Nazaré Cohen
dc.contributor.authorGellen, Laura Patrícia Albarello
dc.contributor.authorMoraes, Francisco Cezar Aquino de
dc.contributor.authorCalderaro, Maria Clara Leite
dc.contributor.authorAssunção, Letícia Almeida de
dc.contributor.authorSilva, Natasha Monte da
dc.contributor.authorPereira, Esdras Edgar Batista
dc.contributor.authorSantos, André Mauricio Ribeiro dos
dc.contributor.authorSantos, Andrea Kely Campos Ribeiro dos
dc.contributor.authorBurbano, Rommel Mario Rodriguez
dc.contributor.authorSouza, Sandro José de
dc.contributor.authorGuerreiro, João Farias
dc.contributor.authorAssumpção, Paulo Pimentel de
dc.contributor.authorSantos, Sidney Emanuel Batista dos
dc.contributor.authorFernandes, Marianne Rodrigues
dc.contributor.authorSantos, Ney Pereira Carneiro dos
dc.date.accessioned2024-03-20T16:13:41Z
dc.date.available2024-03-20T16:13:41Z
dc.date.issued2024-02
dc.description.resumoCoronavirus disease 2019 (COVID-19) is an infection caused by SARS-CoV-2. Genome-wide association studies (GWASs) have suggested a strong association of genetic factors with the severity of the disease. However, many of these studies have been completed in European populations, and little is known about the genetic variability of indigenous peoples’ underlying infection by SARS-CoV-2. The objective of the study is to investigate genetic variants present in the genes AQP3, ARHGAP27, ELF5L, IFNAR2, LIMD1, OAS1 and UPK1A, selected due to their association with the severity of COVID-19, in a sample of indigenous people from the Brazilian Amazon in order to describe potential new and already studied variants. We performed the complete sequencing of the exome of 64 healthy indigenous people from the Brazilian Amazon. The allele frequency data of the population were compared with data from other continental populations. A total of 66 variants present in the seven genes studied were identified, including a variant with a high impact on the ARHGAP27 gene (rs201721078) and three new variants located in the Amazon Indigenous populations (INDG) present in the AQP3, IFNAR2 and LIMD1 genes, with low, moderate and modifier impact, respectivelypt_BR
dc.identifier.citationCOELHO, Rita de Cássia Calderaro; MARTINS, Carlliane Lima e Lins Pinto; PASTANA, Lucas Favacho; RODRIGUES, Juliana Carla Gomes; AGUIAR, Kaio Evandro Cardoso; COHEN-PAES, Amanda de Nazaré; GELLEN, Laura Patrícia Albarello; MORAES, Francisco Cezar Aquino de; CALDERARO, Maria Clara Leite; ASSUNÇÃO, Letícia Almeida de; MONTE, Natasha; PEREIRA, Esdras Edgar Batista; RIBEIRO-DOS-SANTOS, André Maurício; RIBEIRO-DO-SANTOS, BURBANO, Ândrea; RODRIGUEZ, Rommel Mario; SOUZA, Sandro José de; GUERREIRO, João Farias; ASSUMPÇÃO, Paulo Pimentel de; SANTOS, Sidney Emanuel Batista dos; FERNANDES, Marianne Rodrigues; SANTOS, Ney Pereira Carneiro dos. Molecular profile of variants potentially associated with severe forms of COVID-19 in Amazonian indigenous populations. Viruses, [S. l.], v. 16, n. 3, p. 359, fev. 2024. Doi: http://dx.doi.org/10.3390/v16030359. Disponível em: https://www.mdpi.com/1999-4915/16/3/359. Acesso em: 20 mar. 2024pt_BR
dc.identifier.doi10.3390/v16030359
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/57905
dc.languageenpt_BR
dc.publisherMDPI AGpt_BR
dc.subjectCOVID-19pt_BR
dc.subjectSARS-CoV-2pt_BR
dc.subjectCoronaviruspt_BR
dc.subjectAmazonian indigenous populationpt_BR
dc.subjectSNPpt_BR
dc.titleMolecular profile of variants potentially associated with severe forms of COVID-19 in Amazonian indigenous populationspt_BR
dc.typearticlept_BR

Arquivos

Pacote Original

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
MolecularProfileVariants_Souza_2024.pdf
Tamanho:
469.33 KB
Formato:
Adobe Portable Document Format
Descrição:
MolecularProfileVariants_Souza_2024
Nenhuma Miniatura disponível
Baixar

Licença do Pacote

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.45 KB
Formato:
Item-specific license agreed upon to submission
Nenhuma Miniatura disponível
Baixar

Coleções

ICe - Artigos publicados em periódicos
Repositório Institucional - UFRN Campus Universitário Lagoa NovaCEP 59078-970 Caixa postal 1524 Natal/RN - BrasilUniversidade Federal do Rio Grande do Norte© Copyright 2025. Todos os direitos reservados.
Contato+55 (84) 3342-2260 - R232Setor de Repositórios Digitaisrepositorio@bczm.ufrn.br
DSpaceIBICT
OasisBR
LAReferencia
Customizado pela CAT - BCZM