Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report

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dc.contributor.authorOsório, Flávia de L.
dc.contributor.authorSanches, Rafael F.
dc.contributor.authorMacedo, Ligia R.
dc.contributor.authorSantos, Rafael G. dos
dc.contributor.authorMaia-de-Oliveira, João P.
dc.contributor.authorWichert-Ana, Lauro
dc.contributor.authorAraújo, Dráulio Barros de
dc.contributor.authorRiba, Jordi
dc.contributor.authorCrippa, José A.
dc.contributor.authorHallak, Jaime E.
dc.date.accessioned2017-05-26T14:01:34Z
dc.date.available2017-05-26T14:01:34Z
dc.date.issued2015
dc.description.resumoObjectives: Ayahuasca (AYA), a natural psychedelic brew prepared from Amazonian plants and rich in dimethyltryptamine (DMT) and harmine, causes effects of subjective well-being and may therefore have antidepressant actions. This study sought to evaluate the effects of a single dose of AYA in six volunteers with a current depressive episode. Methods: Open-label trial conducted in an inpatient psychiatric unit. Results: Statistically significant reductions of up to 82% in depressive scores were observed between baseline and 1, 7, and 21 days after AYA administration, as measured on the Hamilton Rating Scale for Depression (HAM-D), the Montgomery-Åsberg Depression Rating Scale (MADRS), and the Anxious-Depression subscale of the Brief Psychiatric Rating Scale (BPRS). AYA administration resulted in nonsignificant changes in Young Mania Rating Scale (YMRS) scores and in the thinking disorder subscale of the BPRS, suggesting that AYA does not induce episodes of mania and/or hypomania in patients with mood disorders and that modifications in thought content, which could indicate psychedelic effects, are not essential for mood improvement. Conclusions: These results suggest that AYA has fast-acting anxiolytic and antidepressant effects in patients with a depressive disorder.pt_BR
dc.identifier.citationOSORIO, Flávia de L. et al . Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report. Rev. Bras. Psiquiatr., São Paulo, v. 37, n. 1, p. 13-20, mar. 2015.pt_BR
dc.identifier.doi10.1590/1516-4446-2014-1496
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/23117
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectpsychedelic agentspt_BR
dc.subjectdimethyltryptaminept_BR
dc.subjectharminept_BR
dc.subjectmonoamine oxidase inhibitorspt_BR
dc.subjectmonoamine oxidase inhibitorspt_BR
dc.subjecttherapeutic usept_BR
dc.titleAntidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary reportpt_BR
dc.typearticlept_BR

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