Irish coffee: effects of alcohol and caffeine on object discrimination in zebrafish

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dc.contributor.authorSantos, Luana
dc.contributor.authorOliveira, Julia Ruiz
dc.contributor.authorOliveira, Jéssica J.
dc.contributor.authorSilva, Priscila F.
dc.contributor.authorLuchiari, Ana Carolina
dc.date.accessioned2018-01-18T18:26:30Z
dc.date.available2018-01-18T18:26:30Z
dc.date.issued2016-02-02
dc.description.resumoMany studies regarding the effects of drugs investigate the acute and chronic use of alcohol, but only a few address the effects of caffeine and alcohol combined to the performance of the zebrafish in cognitive tasks. The zebrafish is an importantmodel for studying the effects of drugs on learning, because it has large genetic similarities to humans and the non-invasive administration of the substances favors translational bias of research. In this study, we observed the effects of alcohol and caffeine on zebrafish cognition through an object discrimination test. We noticed that animals subjected to acute alcohol dose and those under alcohol or caffeine withdrawal did not show discrimination. When fish were treated with associated alcohol and caffeine, those chronically treated with alcohol and subjected to moderate acute dose of caffeine showed learning of the task. Our results reinforce the harmful effects of the alcohol use on cognitive tasks, and suggest that continued use of high doses of caffeine cause cognitive impairment during withdrawal of the substance. However, the acute use of caffeine appears to reverse the harmful effects of alcohol withdrawal, allowing discriminative performance equivalent to control fish. Finally, we reiterate the use of zebrafish as a model for drug effects screening and search for active compounds that modulate the alcohol and caffeine effectspt_BR
dc.identifier.citationSANTOS, Luana et al. Irish coffee: effects of alcohol and caffeine on object discrimination in zebrafish. Pharmacology Biochemistry and Behavior, v. 2, p. 100-11, fev. 2016. Disponível em <http://www.sciencedirect.com/science/article/pii/S0091305716300120?via%3Dihub>. Acesso em: 16 out. 2017.pt_BR
dc.identifier.doi10.1016/j.pbb.2016.01.013
dc.identifier.issn0091-3057
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/24583
dc.languageengpt_BR
dc.publisherElsevierpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectPsychoactive drugspt_BR
dc.subjectAlcoholpt_BR
dc.subjectCaffeinept_BR
dc.subjectDiscriminationpt_BR
dc.subjectDanio reriopt_BR
dc.subjectMemorypt_BR
dc.titleIrish coffee: effects of alcohol and caffeine on object discrimination in zebrafishpt_BR
dc.typearticlept_BR

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