Noradrenergic Control of Gene Expression and Long- Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds

Velho, Tarciso André Ferreira; Lu, Kai; Ribeiro, Sidarta Tollendal Gomes; Pinaud, Raphael; Vicario, David; Mello, Claudio V.

Noradrenergic Control of Gene Expression and Long- Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds

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dc.contributor.author	Velho, Tarciso André Ferreira
dc.contributor.author	Lu, Kai
dc.contributor.author	Ribeiro, Sidarta Tollendal Gomes
dc.contributor.author	Pinaud, Raphael
dc.contributor.author	Vicario, David
dc.contributor.author	Mello, Claudio V.
dc.date.accessioned	2017-05-31T12:40:09Z
dc.date.available	2017-05-31T12:40:09Z
dc.date.issued	2012-05-04
dc.description.resumo	Norepinephrine (NE) is thought to play important roles in the consolidation and retrieval of long-term memories, but its role in the processing and memorization of complex acoustic signals used for vocal communication has yet to be determined. We have used a combination of gene expression analysis, electrophysiological recordings and pharmacological manipulations in zebra finches to examine the role of noradrenergic transmission in the brain’s response to birdsong, a learned vocal behavior that shares important features with human speech. We show that noradrenergic transmission is required for both the expression of activity-dependent genes and the long-term maintenance of stimulus-specific electrophysiological adaptation that are induced in central auditory neurons by stimulation with birdsong. Specifically, we show that the caudomedial nidopallium (NCM), an area directly involved in the auditory processing and memorization of birdsong, receives strong noradrenergic innervation. Song-responsive neurons in this area express a-adrenergic receptors and are in close proximity to noradrenergic terminals. We further show that local a-adrenergic antagonism interferes with song-induced gene expression, without affecting spontaneous or evoked electrophysiological activity, thus dissociating the molecular and electrophysiological responses to song. Moreover, a-adrenergic antagonism disrupts the maintenance but not the acquisition of the adapted physiological state. We suggest that the noradrenergic system regulates long-term changes in song-responsive neurons by modulating the gene expression response that is associated with the electrophysiological activation triggered by song. We also suggest that this mechanism may be an important contributor to long-term auditory memories of learned vocalizations.	pt_BR
dc.identifier.issn	1932-6203
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/23263
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	Noradrenergic Control	pt_BR
dc.subject	Gene Expression	pt_BR
dc.subject	Vocalizations	pt_BR
dc.subject	Songbirds	pt_BR
dc.title	Noradrenergic Control of Gene Expression and Long- Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds	pt_BR
dc.type	article	pt_BR