Nootropic effects of LSD: Behavioral, molecular and computational evidence

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dc.contributor.authorOrnelas, Isis M
dc.contributor.authorSilva, Felipe Augusto Cini da
dc.contributor.authorWießner, Isabel
dc.contributor.authorMarcos, Encarni
dc.contributor.authorAraujo, Draulio Barros de
dc.contributor.authorGoto-Silva, Livia
dc.contributor.authorNascimento, Juliana
dc.contributor.authorSilva, Sérgio Ruschi Bergamachi
dc.contributor.authorCosta, Marcelo N
dc.contributor.authorFalchi, Marcelo
dc.contributor.authorOlivieri, Rodolfo
dc.contributor.authorFontes, Fernanda Palhano Xavier de
dc.contributor.authorSequerra, Eduardo Bouth
dc.contributor.authorMartins-de-Souza, Daniel
dc.contributor.authorFeilding, Amanda
dc.contributor.authorCosta, César Rennó
dc.contributor.authorTófoli, Luis Fernando
dc.contributor.authorRehen, Stevens K
dc.contributor.authorRibeiro, Sidarta Tollendal Gomes
dc.date.accessioned2022-07-27T13:32:27Z
dc.date.available2022-07-27T13:32:27Z
dc.date.issued2022-06-19
dc.description.resumoThe therapeutic use of classical psychedelic substances such as d-lysergic acid diethylamide (LSD) surged in recent years. Studies in rodents suggest that these effects are produced by increased neural plasticity, including stimulation of the mTOR pathway, a key regulator of metabolism, plasticity, and aging. Could psychedelic-induced neural plasticity be harnessed to enhance cognition? Here we show that LSD treatment enhanced performance in a novel object recognition task in rats, and in a visuo-spatial memory task in humans. A proteomic analysis of human brain organoids showed that LSD affected metabolic pathways associated with neural plasticity, including mTOR. To gain insight into the relation of neural plasticity, aging and LSD-induced cognitive gains, we emulated the experiments in rats and humans with a neural network model of a cortico-hippocampal circuit. Using the baseline strength of plasticity as a proxy for age and assuming an increase in plasticity strength related to LSD dose, the simulations provided a good fit for the experimental data. Altogether, the results suggest that LSD has nootropic effectspt_BR
dc.identifier.citationORNELAS, Isis M.; CINI, Felipe A.; WIEßNER, Isabel; MARCOS, Encarni; ARAÚJO, Dráulio B.; GOTO-SILVA, Livia; NASCIMENTO, Juliana; SILVA, Sergio R. B.; COSTA, Marcelo N.; FALCHI, Marcelo; OLIVIERI, Rodolfo; PALHANO-FONTES, Fernanda; SEQUERRA, Eduardo; MARTINS-DE-SOUZA, Daniel; FEILDING, Amanda; RENNÓ-COSTA, César; TÓFOLI, Luis Fernando; REHEN, Stevens K; RIBEIRO, Sidarta. Nootropic effects of LSD: behavioral, molecular and computational evidence. Experimental Neurology, [S. l.], v. 356, p. 114148, out. 2022. Doi: http://dx.doi.org/10.1016/j.expneurol.2022.114148. Disponível em: https://www.sciencedirect.com/science/article/pii/S001448862200173X?via%3Dihub. Acesso em: 27 jul. 2022pt_BR
dc.identifier.doi10.1016/j.expneurol.2022.114148
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/48767
dc.languageenpt_BR
dc.publisherElsevier BVpt_BR
dc.subjectCognitionpt_BR
dc.subjectComputational modelpt_BR
dc.subjectHuman brain organoidspt_BR
dc.subjectLysergic Acid Diethylamide (LSD)pt_BR
dc.subjectMemorypt_BR
dc.subjectNeuroplasticitypt_BR
dc.subjectPsychedelicpt_BR
dc.titleNootropic effects of LSD: Behavioral, molecular and computational evidencept_BR
dc.typearticlept_BR

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