5-MeO-DMT induces sleep-like LFP spectral signatures in the hippocampus and prefrontal cortex of awake rats
| dc.contributor.author | Souza, Annie da Costa | |
| dc.contributor.author | Souza, Bryan da Costa | |
| dc.contributor.author | França, Arthur Sergio Cavalcanti de | |
| dc.contributor.author | Moradi, Marzieh | |
| dc.contributor.author | Souza, Nicholy C. | |
| dc.contributor.author | Leão, Emelie Katarina Svahn | |
| dc.contributor.author | Tort, Adriano Bretanha Lopes | |
| dc.contributor.author | Leao, Richardson Naves | |
| dc.contributor.author | Santos, Vítor Lopes dos | |
| dc.contributor.author | Ribeiro, Sidarta Tollendal Gomes | |
| dc.date.accessioned | 2024-07-02T13:50:32Z | |
| dc.date.available | 2024-07-02T13:50:32Z | |
| dc.date.issued | 2024-05 | |
| dc.description.resumo | 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a potent classical psychedelic known to induce changes in locomotion, behaviour, and sleep in rodents. However, there is limited knowledge regarding its acute neurophysiological effects. Local field potentials (LFPs) are commonly used as a proxy for neural activity, but previous studies investigating psychedelics have been hindered by confounding effects of behavioural changes and anaesthesia, which alter these signals. To address this gap, we investigated acute LFP changes in the hippocampus (HP) and medial prefrontal cortex (mPFC) of freely behaving rats, following 5-MeO-DMT administration. 5-MeO-DMT led to an increase of delta power and a decrease of theta power in the HP LFPs, which could not be accounted for by changes in locomotion. Furthermore, we observed a dose-dependent reduction in slow (20–50 Hz) and mid (50–100 Hz) gamma power, as well as in theta phase modulation, even after controlling for the effects of speed and theta power. State map analysis of the spectral profile of waking behaviour induced by 5-MeO-DMT revealed similarities to electrophysiological states observed during slow-wave sleep (SWS) and rapid-eye-movement (REM) sleep. Our findings suggest that the psychoactive effects of classical psychedelics are associated with the integration of waking behaviours with sleep-like spectral patterns in LFPs | pt_BR |
| dc.identifier.citation | SOUZA, Annie C.; SOUZA, Bryan C.; FRANÇA, Arthur; MORADI, Marzieh; SOUZA, Nicholy C.; LEÃO, Katarina E.; TORT, Adriano B. L.; LEÃO, Richardson N.; LOPES-DOS-SANTOS, Vítor; RIBEIRO, Sidarta. 5-MeO-DMT induces sleep-like LFP spectral signatures in the hippocampus and prefrontal cortex of awake rats. Scientific Reports, [S. l.], v. 14, n. 1, p. 11281, maio 2024. Doi: http://dx.doi.org/10.1038/s41598-024-61474-9. Disponível em: https://www.nature.com/articles/s41598-024-61474-9. Acesso em: 02 jul. 2024 | pt_BR |
| dc.identifier.doi | 10.1038/s41598-024-61474-9 | |
| dc.identifier.uri | https://repositorio.ufrn.br/handle/123456789/58527 | |
| dc.language | en | pt_BR |
| dc.publisher | Springer Science and Business Media LLC | pt_BR |
| dc.rights | Attribution 3.0 Brazil | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/br/ | * |
| dc.subject | 5-MeO-DMT | pt_BR |
| dc.subject | Methoxydimethyltryptamines | pt_BR |
| dc.subject | Psychedelics | pt_BR |
| dc.subject | Hallucinogens | pt_BR |
| dc.subject | Hippocampal oscillations | pt_BR |
| dc.subject | Prefrontal cortex | pt_BR |
| dc.title | 5-MeO-DMT induces sleep-like LFP spectral signatures in the hippocampus and prefrontal cortex of awake rats | pt_BR |
| dc.type | article | pt_BR |
Arquivos
Pacote Original
1 - 1 de 1
Nenhuma Miniatura disponível
- Nome:
- 5-MeO-DMTInduces_Ribeiro_2024.pdf
- Tamanho:
- 2.77 MB
- Formato:
- Adobe Portable Document Format
- Descrição:
- 5-MeO-DMTInduces_Ribeiro_2024
Nenhuma Miniatura disponível
Licença do Pacote
1 - 1 de 1
Nenhuma Miniatura disponível
- Nome:
- license.txt
- Tamanho:
- 1.45 KB
- Formato:
- Item-specific license agreed upon to submission
Nenhuma Miniatura disponível