Design of Magnetic Polymeric Particles as a Stimulus-Responsive System for Gastric Antimicrobial Therapy

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dc.contributor.authorCarriço, Artur da Silva
dc.contributor.authorSilva-Freitas, Erica L.
dc.contributor.authorPontes, Thales R. F.
dc.contributor.authorAraújo-Neto, Rafael P.
dc.contributor.authorDamasceno, Ítalo H. M.
dc.contributor.authorSilva, Kátia L.
dc.contributor.authorCarvalho, Juliana F.
dc.contributor.authorMedeiros, Aldo C.
dc.contributor.authorSilva, Rodolfo B.
dc.contributor.authorSilva, Amanda K. A.
dc.contributor.authorMorales, Marco A.
dc.contributor.authorEgito, Eryvaldo S. T.
dc.contributor.authorDantas, Ana L.
dc.date.accessioned2020-04-16T13:10:35Z
dc.date.available2020-04-16T13:10:35Z
dc.date.issued2016-12-13
dc.description.resumoThe treatment of peptic ulcers induced by H. pylori remains challenging due to the deep mucous layer location of bacteria preventing antimicrobial drug access. The present work aimed to design and evaluate in vitro dual responsive (both pH and magnetic field-sensitive) polymeric magnetic particles loaded with amoxicillin as a smart drug carrier for deep mucous layer penetration and in situ drug release. Magnetite particles were produced by the co-precipitation method and subsequently coated with the Eudragit®S100 and amoxicillin by using the spray-drying technique. The physicochemical characterization of the obtained particles was carried out by optical and scanning electron microscopy, X-ray powder diffraction, Fourier transform infrared spectroscopy, nitrogen adsorption/desorption isotherms, and vibrating sample magnetometry. Additionally, drug release tests and antibacterial activity tests were evaluated in vitro. Microparticles presented 17.2 ± 0.4 μm in size and their final composition was 4.3 ± 1.5% of amoxicillin, 87.0 ± 2.3% of Eudragit, and 9.0 ± 0.3% of magnetite. They were both pH and magnetic field responsive while presenting antimicrobial activity. On one side, magnetic field responsiveness of particles is expected to prompt them to reach bacterium niche in deep mucous layer by means of magnetic forces. On the other side, pH responsiveness is expected to enable drug release in the neutral pH of the deep mucous layer, preventing undesired delivery in the acidic gastric lumen. Smart microparticles were designed presenting both pH and magnetic field responsiveness as well as antimicrobial activity. These may be promising assets for peptic ulcer treatment.pt_BR
dc.identifier.citationCARRIÇO, Artur da Silva et al. Design of Magnetic Polymeric Particles as a Stimulus-Responsive System for Gastric Antimicrobial Therapy. AAPS PharmSciTech, v. 17, p. 1-11, 2016. ISSN 1530-9932 versão online. DOI https://doi.org/10.1208/s12249-016-0673-1. Disponível em: https://link.springer.com/article/10.1208/s12249-016-0673-1. Acesso em: 8 abr. 2020.pt_BR
dc.identifier.doihttps://doi.org/10.1208/s12249-016-0673-1
dc.identifier.issn1530-9932
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/28791
dc.languageenpt_BR
dc.publisherSpringer Nature Switzerland AGpt_BR
dc.subjectMagnetic polymeric particlespt_BR
dc.subjectGastric antimicrobial therapypt_BR
dc.titleDesign of Magnetic Polymeric Particles as a Stimulus-Responsive System for Gastric Antimicrobial Therapypt_BR
dc.typearticlept_BR

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