Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog

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dc.contributor.authorSirko, Swetlana
dc.contributor.authorBehrendt, Gwendolyn
dc.contributor.authorJohansson, Pia Annette
dc.contributor.authorTripathi, Pratibha
dc.contributor.authorCosta, Marcos Romualdo
dc.contributor.authorBek, Sarah
dc.contributor.authorHeinrich, Christophe
dc.contributor.authorTiedt, Steffen
dc.contributor.authorColak, Dilek
dc.contributor.authorDichgans, Martin
dc.contributor.authorFischer, Isabel Rebekka
dc.contributor.authorPlesnila, Nikolaus
dc.contributor.authorStaufenbiel, Matthias
dc.contributor.authorHaass, Christian
dc.contributor.authorSnapyan, Marina
dc.contributor.authorSaghatelyan, Armen
dc.contributor.authorLi-Huei, Tsai
dc.contributor.authorFischer, André
dc.contributor.authorGrobe, Kay
dc.contributor.authorDimou, Leda
dc.contributor.authorGötz, Magdalena
dc.date.accessioned2017-06-01T11:54:52Z
dc.date.available2017-06-01T11:54:52Z
dc.date.issued2013-04-04
dc.description.resumoAs a result of brain injury, astrocytes become activated and start to proliferate in the vicinity of the injury site. Recently, we had demonstrated that these reactive astrocytes, or glia, can form self-renewing and multipotent neurospheres in vitro. In the present study, we demonstrate that it is only invasive injury, such as stab wounding or cerebral ischemia, and not noninvasive injury conditions, such as chronic amyloidosis or induced neuronal death, that can elicit this increase in plasticity. Furthermore, we find that Sonic hedgehog (SHH) is the signal that acts directly on the astrocytes and is necessary and sufficient to elicit the stem cell response both in vitro and in vivo. These findings provide a molecular basis for how cells with neural stem cell lineage emerge at sites of brain injury and imply that the high levels of SHH known to enter the brain from extraneural sources after invasive injury can trigger this response.pt_BR
dc.identifier.issn1934-5909
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/23319
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectReactive Gliapt_BR
dc.subjectBrain Acquirept_BR
dc.subjectStem Cell Propertiespt_BR
dc.subjectSonic Hedgehogpt_BR
dc.titleReactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehogpt_BR
dc.typearticlept_BR

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