Olmesartan Prevented Intra-articular Inflammation Induced by Zymosan in Rats

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dc.contributor.authorAraújo, Aurigena Antunes de
dc.contributor.authorGuerra, Gerlane Coelho Bernardo
dc.contributor.authorMenezes, Marília Stefani Souza de
dc.contributor.authorAraújo Júnior, Raimundo Fernandes de
dc.contributor.authorMedeiros, Caroline Addison Carvalho Xavier de
dc.date.accessioned2018-06-16T13:41:17Z
dc.date.available2018-06-16T13:41:17Z
dc.date.issued2016
dc.description.resumoThe objective of this study was to study the effect of olmesartan medoxomil (OLM), an antihypertensive drug, on intra-articular inflammation induced by zymosan (Zy) in Wistar rats. Intra-articular inflammation was induced in the right knees of rats by 1 mg Zy dissolved in saline. The animals were divided into the following groups: saline only (oral saline and intra-articular saline); Zy only (intra-articular Zy and oral saline), and intra-articular Zy and oral OLM (5, 15, or 30 mg/kg) or diclofenac sodium (SD; 100 mg/kg). Twenty-four hours after Zy injection, synovial fluid was collected for total leukocyte counts, blood was collected for biochemical measurements, and synovial tissue was collected for histopathology, immunohistochemistry, immunofluorescence and myeloperoxidase (MPO), malonaldehyde (MDA), and non-protein sulphydryl (NPSH) assays. OLM doses of 15 and 30 mg/kg had protective effects, as evidenced by improved histopathological parameters of synovium, reduced total leukocyte counts, reduced MPO and MDA levels, and increased NPSH group levels compared with the Zy group. OLM reduced immunostaining for cyclooxygenase 2, tumour necrosis factor and interleukin 17 and increased immunostaining for superoxide dismutase and glutathione peroxidase. SD produced similar results. The drugs studied caused no change in biochemical parameters of the animals. OLM showed protective effects in this model of Zy-induced intra-articular inflammation.pt_BR
dc.identifier.citationARAÚJO, Aurigena Antunes de et al. Olmesartan Prevented Intra-articular Inflammation Induced by Zymosan in Rats. Biological & Pharmaceutical Bulletin, v. 39, p. 1793-1801, 2016. Disponível em: <https://www.jstage.jst.go.jp/article/bpb/39/11/39_b16-00296/_article>. Acesso em: 20 mar. 2018.pt_BR
dc.identifier.doihttps://doi.org/10.1248/bpb.b16-00296
dc.identifier.issn1347-5215
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/25431
dc.languageengpt_BR
dc.publisherThe Pharmaceutical Society of Japanpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectOlmesartanpt_BR
dc.subjectZymosanpt_BR
dc.subjectIntra-articular inflammationpt_BR
dc.titleOlmesartan Prevented Intra-articular Inflammation Induced by Zymosan in Ratspt_BR
dc.typearticlept_BR

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