Influence of curcumin supplementation on metabolic and lipid parameters of people living with HIV/AIDS: a randomized controlled trial

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dc.contributor.authorMedeiros, Gidyenne Christine Bandeira Silva de
dc.contributor.authorSilva, Tatiane Andreza Lima
dc.contributor.authorMedeiros, Danielle Coutinho
dc.contributor.authorMedeiros, Rafaela Catherine Silva Cunha
dc.contributor.authorAraújo, Juliany de Souza
dc.contributor.authorMedeiros, Jason Azevedo
dc.contributor.authorUrurahy, Marcela Abbott Galvao
dc.contributor.authorSantos, Ronaldo Vagner Thomatieli
dc.contributor.authorMedeiros, Radames Maciel Vitor
dc.contributor.authorLais, Lucia Leite
dc.contributor.authorDantas, Paulo Moreira Silva
dc.date.accessioned2024-07-31T19:06:01Z
dc.date.available2024-07-31T19:06:01Z
dc.date.issued2019-08
dc.description.resumoBackground: Scientific studies have shown that the potential therapeutic efficacy of curcumin in several diseases is due to its potent antioxidant and anti-inflammatory properties. Consequently, curcumin supplementation seems to be a valuable alternative for HIV-infected individuals. The aim of this study is to evaluate the influence of curcumin supplementation on substrate oxidation at rest, body composition, and the lipid profile of physically active people living with HIV/AIDS under antiretroviral therapy. Methods: This double-blind, crossover, randomized clinical trial was comprised of 20 subjects divided into experimental (EG) and control (CG) groups, receiving 1000 mg curcumin/day and placebo, respectively, during a 30-day period. Substrate oxidation at rest was assessed by indirect calorimetry, body composition was measured by dual-energy x-ray absorptiometry, and the lipid profile was evaluated by blood tests. Data analysis was performed by independent samples and paired t-tests to compare the differences between groups and times. A p-value < 0.05 was accepted as significant. Results: There were no differences between groups regarding substrate oxidation at rest or body composition. However, serum triglyceride levels were increased after curcumin supplementation (182 vs. 219 mg/dL; p = 0.004). Conclusion: Curcumin supplementation promoted the elevation of serum triglyceride levels in HIV-infected subjects. Further studies with a larger sample cohort, different curcumin doses, and longer intervention times are needed to validate current observations. In addition, the influence of physical activity, dietary intake, and genetic polymorphisms must be considered in future studies to better understand the impact of curcumin supplementation on the lipid profile of people living with HIV/AIDS under antiretroviral therapypt_BR
dc.identifier.citationSILVA, Tatiane Andreza Lima; MEDEIROS, Danielle Coutinho; MEDEIROS, Gidyenne Christine Bandeira Silva; MEDEIROS, Rafaela Catherine Silva Cunha; ARAÚJO, Juliany de Souza; MEDEIROS, Jason Azevedo; URURAHY, Marcela Abbott Galvao; SANTOS, Ronaldo Vagner Thomatieli; MEDEIROS, Radames Maciel Vitor; LAIS, Lucia Leite; DANTAS, Paulo Moreira Silva. Influence of curcumin supplementation on metabolic and lipid parameters of people living with HIV/AIDS: a randomized controlled trial. Bmc Complementary and Alternative Medicine, [S.l.], v. 19, n. 1, p. 1-8, 6 ago. 2019. DOI: 10.1186/s12906-019-2620-7. Disponível em: https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-019-2620-7. Acesso em: 10 jul. 2024.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1186/s12906-019-2620-7
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/58919
dc.languageenpt_BR
dc.publisherBMC Complementary and Alternative Medicinept_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectCurcuminpt_BR
dc.subjectDyslipidemiapt_BR
dc.subjectHIVpt_BR
dc.subjectAIDSpt_BR
dc.titleInfluence of curcumin supplementation on metabolic and lipid parameters of people living with HIV/AIDS: a randomized controlled trialpt_BR
dc.typearticlept_BR

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