The functional characterization of callosal connections

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dc.contributor.authorInnocenti, Giorgio M.
dc.contributor.authorSchmidt, Kerstin Erika
dc.contributor.authorMilleret, Chantal
dc.contributor.authorFabri, Mara
dc.contributor.authorKnyazeva, Maria G.
dc.contributor.authorBattaglia-Mayer, Alexandra
dc.contributor.authorAboitiz, Francisco
dc.contributor.authorPtito, Maurice
dc.contributor.authorCaleo, Matteo
dc.contributor.authorMarzi, Carlo A.
dc.contributor.authorBarakovic, Muhamed Roberto Caminiti
dc.contributor.authorLepore, Franco
dc.date.accessioned2021-11-30T14:24:56Z
dc.date.available2021-11-30T14:24:56Z
dc.date.issued2021-11-11
dc.description.resumoThe brain operates through the synaptic interaction of distant neurons within flexible, often heterogeneous, distributed systems. Histological studies have detailed the connections between distant neurons, but their functional characterization deserves further exploration. Studies performed on the corpus callosum in animals and humans are unique in that they capitalize on results obtained from several neuroscience disciplines. Such data inspire a new interpretation of the function of callosal connections and delineate a novel road map, thus paving the way toward a general theory of cortico-cortical connectivity. Here we suggest that callosal axons can drive their post-synaptic targets preferentially when coupled to other inputs endowing the cortical network with a high degree of conditionality. This might depend on several factors, such as their pattern of convergencedivergence, the excitatory and inhibitory operation mode, the range of conduction velocities, the variety of homotopic and heterotopic projections and, finally, the state-dependency of their firing. We propose that, in addition to direct stimulation of post-synaptic targets, callosal axons often play a conditional driving or modulatory role, which depends on task contingencies, as documented by several recent studiespt_BR
dc.identifier.citationINNOCENTI, Giorgio M.; SCHMIDT, Kerstin; MILLERET, Chantal; FABRI, Mara; KNYAZEVA, Maria G.; BATTAGLIA-MAYER, Alexandra; ABOITIZ, Francisco; PTITO, Maurice; CALEO, Matteo; MARZI, Carlo A.; BARAKOVIC, Muhamed Roberto Caminiti; LEPORE, Franco. The functional characterization of callosal connections. Progress In Neurobiology, [S. l.], v. 208, nov. 2021. Doi: http://dx.doi.org/10.1016/j.pneurobio.2021.102186pt_BR
dc.identifier.doi10.1016/j.pneurobio.2021.102186
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/45099
dc.languageenpt_BR
dc.publisherElsevier BVpt_BR
dc.subjectCorpus callosumpt_BR
dc.subjectCallosal axon diameterpt_BR
dc.subjectCallosal conduction velocitypt_BR
dc.subjectCallosal interhemispheric transferpt_BR
dc.titleThe functional characterization of callosal connectionspt_BR
dc.typearticlept_BR

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