α-Tocopherol in breast milk of women with preterm delivery after a single postpartum oral dose of vitamin E

dc.contributor.authorNeves, Renata Alexandra Moreira das
dc.contributor.authorMedeiros, Jeane Franco Pires
dc.contributor.authorRibeiro, Karla Danielly da Silva
dc.contributor.authorLima, Mayara Santa Rosa
dc.contributor.authorLima, Amanda Cibely Pinheiro
dc.contributor.authorDantas, Raquel Costa Silva
dc.contributor.authorSilva, Alyne Batista da
dc.contributor.authorDimenstein, Roberto
dc.contributor.authorIDhttps://orcid.org/0000-0003-1014-0536
dc.contributor.authorIDhttps://orcid.org/0000-0002-2251-5967
dc.contributor.authorIDhttps://orcid.org/0000-0003-3006-7700
dc.contributor.authorIDhttps://orcid.org/0000-0001-8517-6811
dc.date.accessioned2025-05-26T19:54:41Z
dc.date.available2025-05-26T19:54:41Z
dc.date.issued2016-03-02
dc.description.resumoWe evaluated the effect of maternal vitamin E supplementation on the α-tocopherol concentrations of colostrum, transitional milk and mature milk of women who had given birth prematurely. This longitudinal randomised-controlled trial divided eighty-nine women into two groups: a control group and a supplemented group. Blood and breast milk were collected from all the participants after delivery. Next, each woman in the supplemented group received 400 IU of RRR-α-tocopheryl acetate. Further breast milk samples were collected 24 h after the first collection, as well as 7 and 30 d after delivery. α-Tocopherol concentrations were determined by HPLC. The baseline α-tocopherol concentrations in the maternal serum of the two groups were similar: 1159·8 (SD 292·4) μg/dl (27·0 (SD 6·8) μmol/l) for the control group and 1128·3 (SD 407·2) μg/dl (26·2 (SD 9·5) μmol/l) for the supplemented group. None of the women was vitamin E deficient. Breast milk α-tocopherol concentrations increased by 60 % 24 h after supplementation in the intervention group and did not increase at all in the control group. α Tocopherol concentration of the transitional milk in the supplemented group was 35 % higher compared with the control group. α-Tocopherol concentrations of the mature milk in both groups were similar. Maternal supplementation with 400 IU of RRR-α-tocopherol increased the vitamin E concentrations of the colostrum and transitional milk, but not of the mature milk. This study presents relevant information for the design of strategies to prevent and combat vitamin E deficiency in the risk group of preterm infants
dc.identifier.citationMEDEIROS, Jeane Franco Pires; RIBEIRO, Karla Danielly da Silva; LIMA, Mayara Santa Rosa; NEVES, Renata Alexandra Moreira das; LIMA, Amanda Cibely Pinheiro; DANTAS, Raquel Costa Silva; SILVA, Alyne Batista da; DIMENSTEIN, Roberto. α-Tocopherol in breast milk of women with preterm delivery after a single postpartum oral dose of vitamin E. British Journal of Nutrition, [S.l.], v. 115, n. 8, p. 1424-1430, 2 mar. 2016. DOI: 10.1017/s0007114516000477. Disponível em: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/tocopherol-in-breast-milk-of-women-with-preterm-delivery-after-a-single-postpartum-oral-dose-of-vitamin-e/8759423FFED1EC4836659BECFE7C7F74. Acesso em: 8 jul. 2024.
dc.identifier.urihttps://doi.org/10.1017/S0007114516000477
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/63648
dc.language.isoen_US
dc.publisherBritish Journal of Nutrition
dc.subjectDietary supplementation
dc.subjectClinical trials
dc.subjectIntervention studies
dc.subjectLiquid chromatography
dc.titleα-Tocopherol in breast milk of women with preterm delivery after a single postpartum oral dose of vitamin E
dc.typearticle

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