Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study

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dc.contributor.authorMedeiros, Paulo José de
dc.contributor.authorLima, Mabelle Alves Ferreira de
dc.contributor.authorSouza, Karla Simone Costa de
dc.contributor.authorAndrade, César Endrigo Silva de
dc.contributor.authorUrurahy, Marcela Abbott Galvão
dc.contributor.authorAlmeida, José Bruno de
dc.contributor.authorPereira, Maurício Galvão
dc.contributor.authorEvangelista, Karine Cavalcanti Maurício Sena
dc.contributor.authorRezende, Adriana Augusto de
dc.date.accessioned2023-07-31T15:26:24Z
dc.date.available2023-07-31T15:26:24Z
dc.date.issued2023
dc.description.resumoIntroduction: low 25-hydroxyvitamin D [25(OH)D] levels occur after kidney transplantation (KTx), and can be associated with increase the risk of graft loss. This longitudinal study aimed to evaluate the vitamin D status and association with biomarkers of the renal graft function after KTx. Methods: this longitudinal study included 42 patients evaluated at baseline, 3 and 6 months after KTx. Biodemographic, clinical, and biochemical parameters such as 25(OH)D and parathyroid hormone (PTH), and biomarkers of renal graft function, such as creatinine, estimated glomerular filtration rate (eGFR), and urinary albumin/creatinine ratio (ACR), were assessed. Sun exposure was also evaluated. Patients were categorized according to their 25(OH)D levels. Results: at baseline, 25(OH)D levels < 30 ng/mL were found in 43 % patients, and 38 % of these patients failed to improve their 25(OH)D levels by 6 months after KTx. Low 25(OH)D levels occurred regardless of sun exposure. Further, 44 % patients developed albuminuria at 6 months. An increased ACR was observed in patients with 25(OH)D levels < 30 ng/mL (p = 0.002) compared to that in patients with 25(OH)D > 30 ng/ mL. Additionally, 25(OH)D levels were negatively correlated with ACR at 6 months post-KTx (r = -0.444; p = 0.003). Twelve (28.6 %) patients with 25(OH)D levels < 30 ng/mL showed no eGFR recovery until 6 months after KTx. Conclusion: low vitamin D levels and increased albuminuria were observed at 6 months after KTx, even in a region with high sun exposure. The association between vitamin D status and biomarkers of renal graft function after KTx should be explored in further studies.pt_BR
dc.identifier.citationREZENDE, Adriana Augusto de; LIMA, Mabelle Alves Ferreira de; SOUZA, Karla Simone Costa de; ANDRADE, César Endrigo Silva de; URURAHY, Marcela Abbott Galvão; MEDEIROS, Paulo José de; PEREIRA, Maurício Galvão; ALMEIDA, José Bruno de; EVANGELISTA, Karine Cavalcanti Maurício Sena. Vitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal study. Nutrición Hospitalaria, [S.L.], p. 1, 2023. ARAN Ediciones. http://dx.doi.org/10.20960/nh.04024. Disponível em: https://www.nutricionhospitalaria.org/articles/04024/show. Acesso em: 11 jul. 2023.pt_BR
dc.identifier.doihttp://dx.doi.org/10.20960/nh.04024
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/54294
dc.languageenpt_BR
dc.publisherNutrición Hospitalariapt_BR
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/br/*
dc.subjectkidney transplantationpt_BR
dc.subject25-Hydroxyvitamin Dpt_BR
dc.subjecthypovitaminosis Dpt_BR
dc.subjectalbuminuriapt_BR
dc.subjecturinary albumin/creatinine ratiopt_BR
dc.titleVitamin D status and biomarkers of renal graft function after kidney transplantation: a longitudinal studypt_BR
dc.title.alternativeEstado de la vitamina D y biomarcadores de función del injerto renal después del trasplante de riñón: un estudio longitudinalpt_BR
dc.typearticlept_BR

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