Differential expression levels of Sox9 in early neocortical radial glial cells regulate the decision between stem cell maintenance and differentiation

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dc.contributor.authorFabra-Beser, Jaime
dc.contributor.authorAraújo, Jéssica Alves de Medeiros
dc.contributor.authorCoelho, Diego Marques
dc.contributor.authorGoff, Loyal A.
dc.contributor.authorCosta, Marcos Romualdo
dc.contributor.authorMüller, Ulrich
dc.contributor.authorGil-Sanz, Cristina
dc.date.accessioned2021-08-24T11:39:08Z
dc.date.available2021-08-24T11:39:08Z
dc.date.issued2021-08-18
dc.description.resumoRadial glial progenitor cells (RGCs) in the dorsal telencephalon directly or indirectly produce excitatory projection neurons and macroglia of the neocortex. Recent evidence shows that the pool of RGCs is more heterogeneous than originally thought and that progenitor subpopulations can generate particular neuronal cell types. Using single-cell RNA sequencing, we have studied gene expression patterns of RGCs with different neurogenic behavior at early stages of cortical development. At this early age, some RGCs rapidly produce postmitotic neurons, whereas others self-renew and undergo neurogenic divisions at a later age. We have identified candidate genes that are differentially expressed among these early RGC subpopulations, including the transcription factor Sox9. Using in utero electroporation in embryonic mice of either sex, we demonstrate that elevated Sox9 expression in progenitors affects RGC cell cycle duration and leads to the generation of upper layer cortical neurons. Our data thus reveal molecular differences between progenitor cells with different neurogenic behavior at early stages of corticogenesis and indicates that Sox9 is critical for the maintenance of RGCs to regulate the generation of upper layer neuronspt_BR
dc.identifier.citationFABRA-BESER, Jaime; ARAUJO, Jessica Alves Medeiros de; MARQUES-COELHO, Diego; GOFF, Loyal A.; COSTA, Marcos R.; MÜLLER, Ulrich; GIL-SANZ, Cristina. Differential Expression Levels of Sox9 in Early Neocortical Radial Glial Cells Regulate the Decision between Stem Cell Maintenance and Differentiation. The Journal Of Neuroscience, [S. l.], v. 41, n. 33, p. 6969-6986, ago. 2021. http://dx.doi.org/10.1523/jneurosci.2905-20.2021. Disponível em: https://www.jneurosci.org/content/41/33/6969#page. Acesso em: 23 ago. 2021.pt_BR
dc.identifier.doihttps://doi.org/10.1523/JNEUROSCI.2905-20.2021
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/33238
dc.languageenpt_BR
dc.publisherSociety for Neurosciencept_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectCortical developmentpt_BR
dc.subjectProgenitors diversitypt_BR
dc.subjectRadial glia cellspt_BR
dc.subjectSox9pt_BR
dc.titleDifferential expression levels of Sox9 in early neocortical radial glial cells regulate the decision between stem cell maintenance and differentiationpt_BR
dc.typearticlept_BR

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