Dopamine Modulates Delta-Gamma Phase-Amplitude Coupling in the Prefrontal Cortex of Behaving Rats

Andino-Pavlovsky, Victoria; Souza, Annie C.; Scheffer-Teixeira, Robson; Tort, Adriano Bretanha Lopes; Etchenique, Roberto; Ribeiro, Sidarta Tollendal Gomes

Dopamine Modulates Delta-Gamma Phase-Amplitude Coupling in the Prefrontal Cortex of Behaving Rats

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dc.contributor.author	Andino-Pavlovsky, Victoria
dc.contributor.author	Souza, Annie C.
dc.contributor.author	Scheffer-Teixeira, Robson
dc.contributor.author	Tort, Adriano Bretanha Lopes
dc.contributor.author	Etchenique, Roberto
dc.contributor.author	Ribeiro, Sidarta Tollendal Gomes
dc.date.accessioned	2017-05-10T12:08:30Z
dc.date.available	2017-05-10T12:08:30Z
dc.date.issued	2017-05-09
dc.description.resumo	Dopamine release and phase-amplitude cross-frequency coupling (CFC) have independently been implicated in prefrontal cortex (PFC) functioning. To causally investigate whether dopamine release affects phase-amplitude comodulation between different frequencies in local field potentials (LFP) recorded from the medial PFC (mPFC) of behaving rats, we used RuBiDopa, a light-sensitive caged compound that releases the neurotransmitter dopamine when irradiated with visible light. LFP power did not change in any frequency band after the application of light-uncaged dopamine, but significantly strengthened phase-amplitude comodulation between delta and gamma oscillations. Saline did not exert significant changes, while injections of dopamine and RuBiDopa produced a slow increase in comodulation for several minutes after the injection. The results show that dopamine release in the medial PFC shifts phase-amplitude comodulation from theta-gamma to delta-gamma. Although being preliminary results due to the limitation of the low number of animals present in this study, our findings suggest that dopamine-mediated modification of the frequencies involved in comodulation could be a mechanism by which this neurotransmitter regulates functioning in mPFC.	pt_BR
dc.identifier.doi	10.3389/fncir.2017.00029
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/22855
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	LFP oscillation	pt_BR
dc.subject	comodulation	pt_BR
dc.subject	delta-gamma coupling	pt_BR
dc.subject	uncaging	pt_BR
dc.subject	dopamine	pt_BR
dc.title	Dopamine Modulates Delta-Gamma Phase-Amplitude Coupling in the Prefrontal Cortex of Behaving Rats	pt_BR
dc.type	article	pt_BR