Breast milk retinol levels after Vitamin A supplementation at different postpartum amounts and intervals

dc.contributor.authorRibeiro, Karla Danielly da S.
dc.contributor.authorBezerra, Danielle S.
dc.contributor.authorMelo, Andressa T. A. de
dc.contributor.authorOliveira, Kátia C. de A. N. de
dc.contributor.authorAraújo, Karoline Q. M. A. de
dc.contributor.authorMedeiros, Monalisa S. M. de F.
dc.contributor.authorSantos, Flávia A. P. S. dos
dc.contributor.authorMedeiros, Jeane F. P.
dc.contributor.authorLima, Mayara S. R.
dc.contributor.authorSilva, Ana Gabriella C. L. da
dc.contributor.authorDimenstein, Roberto
dc.contributor.authorOsório, Mônica M.
dc.contributor.authorID0000-0002-2251-5967pt_BR
dc.date.accessioned2024-11-28T20:22:33Z
dc.date.available2024-11-28T20:22:33Z
dc.date.issued2022
dc.description.resumoMaternal vitamin A (VA) supplementation in risk areas for Vitamin A deficiency (VAD) was launched to improve the level of this nutrient in nursing mothers and in their breast milk. This longitudinal and randomized study aimed to evaluate the levels of retinol in breast milk after supplementation with VA in varying amounts (200,000 IU or 400,000 IU) and different postpartum intervals. Women were distributed into four intervention groups and given a single 200,000 IU postnatal dosage of VA at time 0 h (postnatal morning) (G200 0H); a single 200,000 IU dosage of VA in week four (G200 4W); 200,000 IU of VA at time 0 h + 200,000 IU of VA 24 h after the first supplementation (G400 24H); and 200,000 IU of VA at time 0 h + 200,000 IU of VA one week after the first supplementation (G400 1W). Breast milk samples were collected over a 12-week period (0 h, 24 h and 1, 4, 12 weeks post-natal). Retinol levels were determined by high-performance liquid chromatography. The Generalized Estimated Equation (GEE) assessed the different retinol levels. The G200 (0H), G400 (24H), and G400 (1W) groups presented higher retinol levels at 24 h than the G200 (4W) group (p < 0.001). The retinol levels of all groups were similar at times 1, 4 and 12 weeks after delivery (p > 0.05). Maternal VA supplementation increased retinol levels in the colostrum. Different supplementation dosages or postpartum administration times did not result in added benefit to retinol levels in mature breast milk.pt_BR
dc.identifier.citationBEZERRA, Danielle S; MELO, Andressa T. A. de, OLIVEIRA, Kátia C. de A. N de; ARAÚJO, Karoline Q. M. A. de; MEDEIROS, Monalisa S. M. de F; SANTOS, Flávia A. P. S. dos; MEDEIROS, Jeane F. P.; LIMA, Mayara S. R.; SILVA, Ana Gabriella C. L. da; RIBEIRO, Karla Danielly da S.; DIMENSTEIN, Roberto; OSÓRIO, Mônica M.;. Breast Milk Retinol Levels after Vitamin A Supplementation at Different Postpartum Amounts and Intervals. Nutrients, v. 14, n. 17, p. 3570, 2022. DOI: http://dx.doi.org/10.3390/nu14173570. Disponível em: https://www.mdpi.com/2072-6643/14/17/3570. Acesso em: 04 out. 2024.pt_BR
dc.identifier.issn2072-6643
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/60703
dc.languageenpt_BR
dc.publisherNutrientspt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectMicronutrientspt_BR
dc.subjectNutritional statuspt_BR
dc.subjectInfant and child nutritionpt_BR
dc.subjectDietary supplementspt_BR
dc.subjectchromatography high pressure liquidpt_BR
dc.titleBreast milk retinol levels after Vitamin A supplementation at different postpartum amounts and intervalspt_BR
dc.typearticlept_BR

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