Asymmetry of the temporal code for space by hippocampal place cells

Souza, Bryan C.; Tort, Adriano Bretanha Lopes

Asymmetry of the temporal code for space by hippocampal place cells

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dc.contributor.author	Souza, Bryan C.
dc.contributor.author	Tort, Adriano Bretanha Lopes
dc.date.accessioned	2017-08-18T13:13:44Z
dc.date.available	2017-08-18T13:13:44Z
dc.date.issued	2017-08-17
dc.description.resumo	Hippocampal place cells convey spatial information through spike frequency (“rate coding”) and spike timing relative to the theta phase (“temporal coding”). Whether rate and temporal coding are due to independent or related mechanisms has been the subject of wide debate. Here we show that the spike timing of place cells couples to theta phase before major increases in firing rate, anticipating the animal’s entrance into the classical, rate-based place field. In contrast, spikes rapidly decouple from theta as the animal leaves the place field and firing rate decreases. Therefore, temporal coding has strong asymmetry around the place field center. We further show that the dynamics of temporal coding along space evolves in three stages as the animal traverses the place field: phase coupling, sharp precession and phase decoupling. These results suggest that independent mechanisms may govern rate and temporal coding.	pt_BR
dc.identifier.doi	10.1038/s41598-017-08609-3
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/23764
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	rate coding	pt_BR
dc.subject	temporal coding	pt_BR
dc.subject	hippocampus	pt_BR
dc.subject	theta phase	pt_BR
dc.title	Asymmetry of the temporal code for space by hippocampal place cells	pt_BR
dc.type	article	pt_BR