Effects of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with metabolic syndrome: a protocol for systematic review and meta-analysis of randomized controlled trials

Página do item simplificado Estatísticas
dc.contributor.authorEvangelista, Karine Cavalcanti Maurício de Sena
dc.contributor.authorAquino, Séphora Louyse Silva
dc.contributor.authorCunha, Aline Tuane Oliveira
dc.contributor.authorLima, Josivan Gomes
dc.contributor.authorOliveira, Antonio Gouveia
dc.contributor.authorCobucci, Ricardo Ney
dc.contributor.authorPedrosa, Lucia Fatima Campos
dc.date.accessioned2024-08-23T19:45:34Z
dc.date.available2024-08-23T19:45:34Z
dc.date.issued2020-08
dc.description.resumoBackground: Vitamin D deficiency can play a role in extraskeletal functions that are involved with a set of risk factors associated with metabolic syndrome (MetS). The purpose of this review is to investigate the impact of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with MetS. Methods: EMBASE, Medline, Web of Science, Lilacs, the Cochrane Central Register of Controlled Trials, clinicaltrials.gov databases, and grey literature will be systematically searched for randomized controlled trials (RCTs) of vitamin D supplementation compared with placebo, through December 2020. We will include in the study patients with MetS diagnosed by the criteria set forth by the National Cholesterol Education Program Adult Treatment Panel III or the International Diabetes Federation. The effect of oral vitamin D supplementation on lipid profile improvement (triglycerides, high-density lipoprotein cholesterol—HDL-C) is this review’s primary outcome. The systematic review will be performed following the Preferred Reporting Items for Systematic Reviews and MetaAnalyses (PRISMA) guidelines. The study screening, data extraction, and quality assessment will be fulfilled by two independent reviewers according to the Cochrane Risk of Bias tool (RoB 2.0). The results of the systematic review will be provided according to the type of intervention, characteristics of the target population, the methods of measurement of vitamin D, the calculated vitamin D concentrations, types of biological samples, and types of outcomes. Meta-analyses will be conducted where appropriate. The Cochran’s Q test and the I 2 -heterogeneity test will be used to assess the presence of heterogeneity and whether the fixed or the random-effects model would be appropriate for combining study results using the inverse variance method or the DerSimonian-Lair method, respectively. Publication bias will be evaluated using funnel plots and Egger’s and Begg’s tests. The strength of the evidence will be assessed according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Discussion: This systematic review will assess the effects of vitamin D supplementation on fasting glucose and triglyceride levels, waist circumference and mean blood pressure, and HDL-C among individuals with MetS. These findings may assist with decision-making within a clinical settingpt_BR
dc.identifier.citationAQUINO, Séphora Louyse Silva; CUNHA, Aline Tuane Oliveira; LIMA, Josivan Gomes; EVANGELISTA, Karine Cavalcanti Maurício de Sena; OLIVEIRA, Antonio Gouveia; COBUCCI, Ricardo Ney; PEDROSA, Lucia Fatima Campos. Effects of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with metabolic syndrome: a protocol for systematic review and meta-analysis of randomized controlled trials. Systematic Reviews, [S.l.], v. 9, n. 1, p. 1-6, 11 ago. 2020. DOI: 10.1186/s13643-020-01433-3. Disponível em: https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-020-01433-3. Acesso em: 25 jul. 2024.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1186/s13643-020-01433-3
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/59849
dc.languageenpt_BR
dc.publisherSystematic Reviewspt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectMetabolic syndromept_BR
dc.subjectVitamin D supplementationpt_BR
dc.subjectSystematic reviewpt_BR
dc.subjectRandomized controlled trialspt_BR
dc.titleEffects of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with metabolic syndrome: a protocol for systematic review and meta-analysis of randomized controlled trialspt_BR
dc.typearticlept_BR

Arquivos

Pacote Original

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
EffectsVitaminD_Aquino_2020.pdf
Tamanho:
522.18 KB
Formato:
Adobe Portable Document Format
Nenhuma Miniatura disponível
Baixar

Licença do Pacote

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.45 KB
Formato:
Item-specific license agreed upon to submission
Nenhuma Miniatura disponível
Baixar

Coleções

CCS - DNUT - Artigos publicados em periódicos
Repositório Institucional - UFRN Campus Universitário Lagoa NovaCEP 59078-970 Caixa postal 1524 Natal/RN - BrasilUniversidade Federal do Rio Grande do Norte© Copyright 2025. Todos os direitos reservados.
Contato+55 (84) 3342-2260 - R232Setor de Repositórios Digitaisrepositorio@bczm.ufrn.br
DSpaceIBICT
OasisBR
LAReferencia
Customizado pela CAT - BCZM