Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial

Página do item simplificado Estatísticas
dc.contributor.authorPalhano-Fontes, Fernanda
dc.contributor.authorBarreto, Dayanna
dc.contributor.authorOnias, Heloisa
dc.contributor.authorAndrade, Katia C.
dc.contributor.authorNovaes, Morgana M.
dc.contributor.authorPessoa, Jessica A.
dc.contributor.authorMota-Rolim, Sergio A.
dc.contributor.authorOsório, Flávia L.
dc.contributor.authorSanches, Rafael
dc.contributor.authorSantos, Rafael G. dos
dc.contributor.authorTófoli, Luís Fernando
dc.contributor.authorSilveira, Gabriela de Oliveira
dc.contributor.authorYonamine, Mauricio
dc.contributor.authorRiba, Jordi
dc.contributor.authorSantos, Francisco R.
dc.contributor.authorSilva-Junior, Antonio A.
dc.contributor.authorAlchieri, João C.
dc.contributor.authorGalvão-Coelho, Nicole L.
dc.contributor.authorLobão-Soares, Bruno
dc.contributor.authorHallak, Jaime E. C.
dc.contributor.authorArcoverde, Emerson
dc.contributor.authorMaia-de-Oliveira, João P.
dc.contributor.authorAraújo, Dráulio Barros de
dc.date.accessioned2018-06-18T12:58:27Z
dc.date.available2018-06-18T12:58:27Z
dc.date.issued2018-06-15
dc.description.resumoBackground Recent open-label trials show that psychedelics, such as ayahuasca, hold promise as fast-onset antidepressants in treatment-resistant depression. Methods To test the antidepressant effects of ayahuasca, we conducted a parallel-arm, double-blind randomized placebo-controlled trial in 29 patients with treatment-resistant depression. Patients received a single dose of either ayahuasca or placebo. We assessed changes in depression severity with the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Hamilton Depression Rating scale at baseline, and at 1 (D1), 2 (D2), and 7 (D7) days after dosing. Results We observed significant antidepressant effects of ayahuasca when compared with placebo at all-time points. MADRS scores were significantly lower in the ayahuasca group compared with placebo at D1 and D2 (p = 0.04), and at D7 (p < 0.0001). Between-group effect sizes increased from D1 to D7 (D1: Cohen's d = 0.84; D2: Cohen's d = 0.84; D7: Cohen's d = 1.49). Response rates were high for both groups at D1 and D2, and significantly higher in the ayahuasca group at D7 (64% v. 27%; p = 0.04). Remission rate showed a trend toward significance at D7 (36% v. 7%, p = 0.054). Conclusions To our knowledge, this is the first controlled trial to test a psychedelic substance in treatment-resistant depression. Overall, this study brings new evidence supporting the safety and therapeutic value of ayahuasca, dosed within an appropriate setting, to help treat depression. This study is registered at http://clinicaltrials.gov (NCT02914769).pt_BR
dc.identifier.citationPALHANO-FONTES et al. Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial. Psychological Medicine, [s.l], p. 1-9, jun./2018.pt_BR
dc.identifier.doihttps://doi.org/10.1017/S0033291718001356
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/25439
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectPsychedelicpt_BR
dc.subjectHallucinogenspt_BR
dc.subjectBanisteriopsispt_BR
dc.subjectAyahuascapt_BR
dc.subjectAntidepressive agentspt_BR
dc.subjectDepressionpt_BR
dc.subjectRandomized Controlled Trial (RCT)pt_BR
dc.subjectHRSpt_BR
dc.subjectMEQpt_BR
dc.titleRapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trialpt_BR
dc.typearticlept_BR

Arquivos

Pacote Original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
DraulioAraujo_ICe_rapid antidepressant effects_2018.pdf
Tamanho:
379.69 KB
Formato:
Adobe Portable Document Format
Descrição:
DraulioAraujo_ICe_rapid antidepressant effects_2018
Imagem de Miniatura
 Baixar

Licença do Pacote

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Nenhuma Miniatura disponível
Baixar

Coleções

ICe - Artigos publicados em periódicos
Repositório Institucional - UFRN Campus Universitário Lagoa NovaCEP 59078-970 Caixa postal 1524 Natal/RN - BrasilUniversidade Federal do Rio Grande do Norte© Copyright 2025. Todos os direitos reservados.
Contato+55 (84) 3342-2260 - R232Setor de Repositórios Digitaisrepositorio@bczm.ufrn.br
DSpaceIBICT
OasisBR
LAReferencia
Customizado pela CAT - BCZM