Contribuições para a análise de sinais neuronais e biomédicos

dc.contributor.advisorBrandão, Gláucio Bezerrapt_BR
dc.contributor.advisor-co1Ribeiro, Sidarta Tollendal Gomespt_BR
dc.contributor.advisor-co1IDpor
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/0649912135067700por
dc.contributor.advisorIDpor
dc.contributor.advisorLatteshttp://lattes.cnpq.br/0050402182466103por
dc.contributor.authorSantos, Vítor Lopes dospt_BR
dc.contributor.authorIDpor
dc.contributor.authorLatteshttp://lattes.cnpq.br/6484208511184541por
dc.contributor.referees1Silva, Mauro Copelli Lopes dapt_BR
dc.contributor.referees1IDpor
dc.contributor.referees1Latteshttp://lattes.cnpq.br/9400915429521069por
dc.date.accessioned2014-12-17T14:55:49Z
dc.date.available2011-12-06pt_BR
dc.date.available2014-12-17T14:55:49Z
dc.date.issued2011-03-03pt_BR
dc.description.abstractFollowing the new tendency of interdisciplinarity of modern science, a new field called neuroengineering has come to light in the last decades. After 2000, scientific journals and conferences all around the world have been created on this theme. The present work comprises three different subareas related to neuroengineering and electrical engineering: neural stimulation; theoretical and computational neuroscience; and neuronal signal processing; as well as biomedical engineering. The research can be divided in three parts: (i) A new method of neuronal photostimulation was developed based on the use of caged compounds. Using the inhibitory neurotransmitter GABA caged by a ruthenium complex it was possible to block neuronal population activity using a laser pulse. The obtained results were evaluated by Wavelet analysis and tested by non-parametric statistics. (ii) A mathematical method was created to identify neuronal assemblies. Neuronal assemblies were proposed as the basis of learning by Donald Hebb remain the most accepted theory for neuronal representation of external stimuli. Using the Marcenko-Pastur law of eigenvalue distribution it was possible to detect neuronal assemblies and to compute their activity with high temporal resolution. The application of the method in real electrophysiological data revealed that neurons from the neocortex and hippocampus can be part of the same assembly, and that neurons can participate in multiple assemblies. (iii) A new method of automatic classification of heart beats was developed, which does not rely on a data base for training and is not specialized in specific pathologies. The method is based on Wavelet decomposition and normality measures of random variables. Throughout, the results presented in the three fields of knowledge represent qualification in neural and biomedical engineeringeng
dc.description.resumoFollowing the new tendency of interdisciplinarity of modern science, a new field called neuroengineering has come to light in the last decades. After 2000, scientific journals and conferences all around the world have been created on this theme. The present work comprises three different subareas related to neuroengineering and electrical engineering: neural stimulation; theoretical and computational neuroscience; and neuronal signal processing; as well as biomedical engineering. The research can be divided in three parts: (i) A new method of neuronal photostimulation was developed based on the use of caged compounds. Using the inhibitory neurotransmitter GABA caged by a ruthenium complex it was possible to block neuronal population activity using a laser pulse. The obtained results were evaluated by Wavelet analysis and tested by non-parametric statistics. (ii) A mathematical method was created to identify neuronal assemblies. Neuronal assemblies were proposed as the basis of learning by Donald Hebb remain the most accepted theory for neuronal representation of external stimuli. Using the Marcenko-Pastur law of eigenvalue distribution it was possible to detect neuronal assemblies and to compute their activity with high temporal resolution. The application of the method in real electrophysiological data revealed that neurons from the neocortex and hippocampus can be part of the same assembly, and that neurons can participate in multiple assemblies. (iii) A new method of automatic classification of heart beats was developed, which does not rely on a data base for training and is not specialized in specific pathologies. The method is based on Wavelet decomposition and normality measures of random variables. Throughout, the results presented in the three fields of knowledge represent qualification in neural and biomedical engineeringpor
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.formatapplication/pdfpor
dc.identifier.citationSANTOS, Vítor Lopes dos. Contribuições para a análise de sinais neuronais e biomédicos. 2011. 48 f. Dissertação (Mestrado em Automação e Sistemas; Engenharia de Computação; Telecomunicações) - Universidade Federal do Rio Grande do Norte, Natal, 2011.por
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/15354
dc.languageporpor
dc.publisherUniversidade Federal do Rio Grande do Nortepor
dc.publisher.countryBRpor
dc.publisher.departmentAutomação e Sistemas; Engenharia de Computação; Telecomunicaçõespor
dc.publisher.initialsUFRNpor
dc.publisher.programPrograma de Pós-Graduação em Engenharia Elétricapor
dc.rightsAcesso Abertopor
dc.subjectneuroengenharia, fotoestimulação neural, postulado de Hebb, assembleias neurais, Lei do semicírculo de Wigner, Teoria da Informação, divergência de Kullback-Leiblerpor
dc.subject.cnpqCNPQ::ENGENHARIAS::ENGENHARIA ELETRICApor
dc.titleContribuições para a análise de sinais neuronais e biomédicospor
dc.typemasterThesispor

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