Social isolation disrupts hippocampal neurogenesis in young non-human primates

Cinini, Simone M.; Barnabe, Gabriela F.; Galvão-Coelho, Nicole; Medeiros, Magda A. de; Perez-Mendes, Patrícia; Sousa, Maria Bernardete Cordeiro de; Covolan, Luciene; Mello, Luiz E.

Social isolation disrupts hippocampal neurogenesis in young non-human primates

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dc.contributor.author	Cinini, Simone M.
dc.contributor.author	Barnabe, Gabriela F.
dc.contributor.author	Galvão-Coelho, Nicole
dc.contributor.author	Medeiros, Magda A. de
dc.contributor.author	Perez-Mendes, Patrícia
dc.contributor.author	Sousa, Maria Bernardete Cordeiro de
dc.contributor.author	Covolan, Luciene
dc.contributor.author	Mello, Luiz E.
dc.date.accessioned	2017-05-31T13:34:08Z
dc.date.available	2017-05-31T13:34:08Z
dc.date.issued	2014-03
dc.description.resumo	Social relationships are crucial for the development and maintenance of normal behavior in non-human primates. Animals that are raised in isolation develop abnormal patterns of behavior that persist even when they are later reunited with their parents. In rodents, social isolation is a stressful event and is associated with a decrease in hippocampal neurogenesis but considerably less is known about the effects of social isolation in non-human primates during the transition from adolescence to adulthood. To investigate how social isolation affects young marmosets, these were isolated from other members of the colony for 1 or 3 weeks and evaluated for alterations in their behavior and hippocampal cell proliferation. We found that anxiety-related behaviors like scent-marking and locomotor activity increased after social isolation when compared to baseline levels. In agreement, grooming-an indicative of attenuation of tension-was reduced among isolated marmosets. These results were consistent with increased cortisol levels after 1 and 3 weeks of isolation. After social isolation (1 or 3 weeks), reduced proliferation of neural cells in the subgranular zone of dentate granule cell layer was identified and a smaller proportion of BrdU-positive cells underwent neuronal fate (doublecortin labeling). Our data is consistent with the notion that social deprivation during the transition from adolescence to adulthood leads to stress and produces anxiety-like behaviors that in turn might affect neurogenesis and contribute to the deleterious consequences of prolonged stressful conditions.	pt_BR
dc.identifier.doi	10.3389/fnins.2014.00045
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/23276
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	anxiety	pt_BR
dc.subject	hippocampal neurogenesis	pt_BR
dc.subject	isolation stress	pt_BR
dc.subject	social isolation	pt_BR
dc.subject	young marmosets	pt_BR
dc.title	Social isolation disrupts hippocampal neurogenesis in young non-human primates	pt_BR
dc.type	article	pt_BR