Moderators of ayahuasca’s biological antidepressant action

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dc.contributor.authorSousa Júnior, Geovan Menezes de
dc.contributor.authorTavares, Vagner Deuel de Oliveira
dc.contributor.authorGalvão, Ana Cecília de Menezes
dc.contributor.authorAlmeida, Raíssa Nóbrega de
dc.contributor.authorFontes, Fernanda Palhano Xavier de
dc.contributor.authorSoares, Bruno Lobão
dc.contributor.authorFreire, Fúlvio Aurélio de Morais
dc.contributor.authorNunes, Emerson Arcoverde
dc.contributor.authorOliveira, João Paulo Maia de
dc.contributor.authorPerkins, Daniel
dc.contributor.authorSarris, Jerome
dc.contributor.authorAraujo, Draulio Barros de
dc.contributor.authorCoelho, Nicole Leite Galvão
dc.date.accessioned2023-01-30T13:01:22Z
dc.date.available2023-01-30T13:01:22Z
dc.date.issued2022-12
dc.description.resumoIntroduction: The understanding of biological responses to psychedelics with antidepressant potential is imperative. Here we report how a set of acute parameters, namely emotional (depressive symptoms), cognitive (psychedelic experience), and physiological (salivary cortisol), recorded during an ayahuasca dosing session, modulated serum brain-derived neurotrophic factor (BDNF), serum cortisol (SC), serum interleukin 6 (IL-6), plasma C-reactive protein (CRP), and salivary cortisol awakening response (CAR). Methods: Results were analyzed 2 days after the psychedelic intervention (ayahuasca) versus placebo in both patients with treatment-resistant depression and healthy volunteers. These measures were assessed as part of a randomized double-blinded, placebo-controlled trial (n = 72). Results: Results revealed that larger reductions of depressive symptoms during the dosing session significantly moderated higher levels of SC in patients. Whereas lesser changes in salivary cortisol levels during the ayahuasca intervention were related to higher BDNF levels in patients with a larger clinical response in the reduction in depressive symptoms. No moderator was found for patient's CAR, IL-6, and CRP responses to ayahuasca and for all biomarker responses to ayahuasca in healthy controls and in the placebo group. Discussion: In summary, some specific emotional and physiological parameters during experimental ayahuasca session were revealed as critical moderators of the improvement of major depression biomarkers, mainly BDNF and SC two days after ayahuasca intake. These findings contribute to paving the way for future studies investigating the biological antidepressant response to psychedelic therapypt_BR
dc.identifier.citationSOUSA, Geovan Menezes de; TAVARES, Vagner Deuel de Oliveira; GALVÃO, Ana Cecília de Menezes; ALMEIDA, Raíssa Nóbrega de; PALHANO-FONTES, Fernanda; LOBÃO-SOARES, Bruno; FREIRE, Fúlvio Aurélio de Morais; NUNES, Emerson Arcoverde; MAIA-DE-OLIVEIRA, João Paulo; PERKINS, Daniel; SARRIS, Jerome; ARAUJO, Draulio Barros de; GALVÃO-COELHO, Nicole Leite. Moderators of ayahuasca’s biological antidepressant action. Frontiers In Psychiatry, [S. l.], v. 13, p. 1033816, dez. 2022. Doi: http://dx.doi.org/10.3389/fpsyt.2022.1033816. Disponível em: https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1033816/full. Acesso em: 30 jan. 2023pt_BR
dc.identifier.doi10.3389/fpsyt.2022.1033816
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/51078
dc.languageenpt_BR
dc.publisherFrontiers Media SApt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectBrain-derived neurotrophic factorpt_BR
dc.subjectHydrocortisonept_BR
dc.subjectCortisolpt_BR
dc.subjectDepressionpt_BR
dc.subjectHallucinogenspt_BR
dc.subjectPsychedelicspt_BR
dc.subjectBanisteriopsispt_BR
dc.subjectAyahuascapt_BR
dc.titleModerators of ayahuasca’s biological antidepressant actionpt_BR
dc.typearticlept_BR

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