Incidence and clinical outcome of Coronavirus disease 2019 in a cohort of 11,560 brazilian patients with multiple sclerosis

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dc.contributor.authorDourado Junior, Mário Emílio Teixeira
dc.contributor.authorFerreira, Lis Campos
dc.contributor.authorSousa, Nise Alessandra de Carvalho
dc.contributor.authorIDhttps://orcid.org/0000-0002-9462-2294pt_BR
dc.date.accessioned2023-07-26T18:18:43Z
dc.date.available2023-07-26T18:18:43Z
dc.date.issued2021
dc.description.resumoBackground:Little information is available regarding the incidence and clinical outcome of the SARS-CoV2 infection in patients with multiple sclerosis (pwMS). Objective:To determine the incidence, clinical outcome, and impact of COVID-19 on pwMS. Methods:This observational study was prospectively performed on a cohort of pwMS (N = 11,560) followed up by 47 out of 51 Brazilian MS referral centers that registered pwMS with COVID-19 at the REDONE platform from 13 March to 4 June 2020. Results:The incidence of COVID-19 for pwMS patients was 27.7/10,000 patients and for the general population was 29.2/10,000 inhabitants. A total of 94 (77 women) pwMS patients, aged 40 ± 10.25 years, presenting 9.9 ± 8.6 years of MS disease duration, developed the COVID-19, most of them (87%) exhibited the mild form of the disease. Eighty (96%) patients maintained the use of MS disease-modifying treatment (DMT) during COVID-19 pandemic and 14 patients were not in use of DMTs. Conclusion:Incidence of COVID-19 in Brazilian pwMS was not different from those observed for the general Brazilian population. Most pwMS exhibited mild COVID-19, despite the maintenance of the underlying MS treatment.pt_BR
dc.identifier.citationDOURADO JUNIOR, Mario Emilio Teixeira; FERREIRA, Lis Campos; SOUSA, Nise Alessandra de Carvalho; FERREIRA, Maria Lucia Brito; DIAS-CARNEIRO, Rafael Paternò Castello; MENDES, Maria Fernanda; PICCOLO, Ana Claudia; THOMAZ, Rodrigo Barbosa; VASCONCELOS, Claudia Cristina Ferreira; ALVES-LEON, Soniza Vieira. Incidence and clinical outcome of Coronavirus disease 2019 in a cohort of 11,560 Brazilian patients with multiple sclerosis. Multiple Sclerosis Journal, [S.L.], v. 27, n. 10, p. 1615-1619, 2 fev. 2021. SAGE Publications. http://dx.doi.org/10.1177/1352458520978354. Disponível em: https://journals.sagepub.com/doi/10.1177/1352458520978354. Acesso em: 14 jul. 2023.pt_BR
dc.identifier.doi10.1177/1352458520978354
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/54206
dc.languageenpt_BR
dc.publisherMultiple Sclerosis Journalpt_BR
dc.subjectmultiple sclerosispt_BR
dc.subjectcovid-19pt_BR
dc.subjectvirus infection sars-cov2pt_BR
dc.titleIncidence and clinical outcome of Coronavirus disease 2019 in a cohort of 11,560 brazilian patients with multiple sclerosispt_BR
dc.typearticlept_BR

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