Dual immune effect of iNKT cells considering human cutaneous and visceral leishmaniasis: an example of cell plasticity according to different disease scenarios

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dc.contributor.authorMaciel, Bruna Leal Lima
dc.contributor.authorMacêdo, Bruna de Góis
dc.contributor.authorPeixoto, Rephany Fonseca
dc.contributor.authorGomes, Julliana de Assis Silva
dc.contributor.authorAzevedo, Fátima de Lourdes Assunção Araújo de
dc.contributor.authorVeras, Robson Cavalcanti
dc.contributor.authorMedeiros, Isac Almeida de
dc.contributor.authorGrisi, Teresa Cristina Soares de Lima
dc.contributor.authorAraújo, Demétrius Antônio Machado de
dc.contributor.authorAmaral, Ian Porto Gurgel do
dc.contributor.authorLima, Tatjana Keesen de Souza
dc.date.accessioned2024-02-01T17:13:09Z
dc.date.available2024-02-01T17:13:09Z
dc.date.issued2018-05
dc.description.resumoAlthough the semi-invariant natural killer T cells (iNKT) are a small subpopulation of cells in the peripheral blood, they are presumed to play a role in early stages of infection against various pathogens, including protozoa. This work investigates the activation status and cytokine profile of iNKT cells during human Leishmania infantum and Leishmania braziliensis infection. We studied iNKT cells in patients with symptomatic active visceral leishmaniasis (AVL) (n = 8), patients with symptomatic active cutaneous leishmaniasis (ACL) (n = 13), negative endemic controls (NEC) (n = 6) and non-endemic controls (NonEC) (n = 6), with and without total Leishmania antigen stimulus (TLA). The number of iNKT cells in the peripheral blood of patients with ACL and AVL unaltered in relation to control groups. Moreover, the iNKT cells from ACL showed a hyperactivation profile compared to patients with AVL. Additionally, TLA induced IFN-gamma production in iNKT cells from patients with ACL, while in iNKT of patients with AVL, TLA induced a decrease in this cytokine. Higher IL-17 and IL-10 production by iNKT cells from patients with ACL were also observed compared to all other groups. There were no changes in iNKT IL-10-producing cells in AVL after TLA stimulation. However, TLA induced increase in IL-10 in iNKT cells in patients with ACL. These findings suggest that, although iNKT cells showed distinct profiles in patients with ACL and AVL, they play a dual role in immune modulation in both Leishmania infectionspt_BR
dc.identifier.citationMACÊDO, Bruna de Góis; PEIXOTO, Rephany Fonseca; MACIEL, Bruna Leal Lima; GOMES, Julliana de Assis Silva; AZEVEDO, Fátima de Lourdes Assunção Araújo de; VERAS, Robson Cavalcanti; MEDEIROS, Isac Almeida de; GRISI, Teresa Cristina Soares de Lima; ARAÚJO, Demétrius Antônio Machado de; AMARAL, Ian Porto Gurgel do; LIMA, Tatjana Keesen de Souza. Dual immune effect of iNKT cells considering human cutaneous and visceral leishmaniasis: an example of cell plasticity according to different disease scenarios. Scandinavian Journal of Immunology, [S.l.], v. 87, n. 6, p. 1-9, 14 mai. 2018. DOI: 10.1111/sji.12668. Disponível em: https://onlinelibrary.wiley.com/doi/10.1111/sji.12668. Acesso em: 30 jan. 2024.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1111/sji.12668
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/57472
dc.languageenpt_BR
dc.publisherScandinavian Journal of Immunologypt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectDual immunept_BR
dc.subjectiNKT cellspt_BR
dc.subjectT cellspt_BR
dc.subjectVisceral leishmaniasispt_BR
dc.titleDual immune effect of iNKT cells considering human cutaneous and visceral leishmaniasis: an example of cell plasticity according to different disease scenariospt_BR
dc.typearticlept_BR

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