Impaired theta-gamma coupling in APP-defcient mice

Zhang, Xiaomin; Zhong, Wewei; Brankačk, Jurij; Weyer, Sascha W.; Müller, Ulrike C.; Tort, Adriano Bretanha Lopes; Draguhn, Andreas

Impaired theta-gamma coupling in APP-defcient mice

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dc.contributor.author	Zhang, Xiaomin
dc.contributor.author	Zhong, Wewei
dc.contributor.author	Brankačk, Jurij
dc.contributor.author	Weyer, Sascha W.
dc.contributor.author	Müller, Ulrike C.
dc.contributor.author	Tort, Adriano Bretanha Lopes
dc.contributor.author	Draguhn, Andreas
dc.date.accessioned	2017-05-24T18:24:55Z
dc.date.available	2017-05-24T18:24:55Z
dc.date.issued	2016-02-24
dc.description.resumo	Amyloid precursor protein (APP) is critically involved in the pathophysiology of Alzheimer's disease, but its physiological functions remain elusive. Importantly, APP knockout (APP-KO) mice exhibit cognitive deficits, suggesting that APP plays a role at the neuronal network level. To investigate this possibility, we recorded local field potentials (LFPs) from the posterior parietal cortex, dorsal hippocampus and lateral prefrontal cortex of freely moving APP-KO mice. Spectral analyses showed that network oscillations within the theta- and gamma-frequency bands were not different between APP-KO and wild-type mice. Surprisingly, however, while gamma amplitude coupled to theta phase in all recorded regions of wild-type animals, in APP-KO mice theta-gamma coupling was strongly diminished in recordings from the parietal cortex and hippocampus, but not in LFPs recorded from the prefrontal cortex. Thus, lack of APP reduces oscillatory coupling in LFP recordings from specific brain regions, despite not affecting the amplitude of the oscillations. Together, our findings reveal reduced cross-frequency coupling as a functional marker of APP deficiency at the network level.	pt_BR
dc.identifier.doi	10.1038/srep21948
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/23067
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	theta-gamma	pt_BR
dc.subject	amyloid precursor protein	pt_BR
dc.subject	Alzheimer disease	pt_BR
dc.title	Impaired theta-gamma coupling in APP-defcient mice	pt_BR
dc.type	article	pt_BR