Satietogenic protein from tamarind seeds decreases food intake, leptin plasma and CCK-1r gene expression in obese wistar rats

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dc.contributor.authorMaciel, Bruna Leal Lima
dc.contributor.authorCosta, Izael De Souza
dc.contributor.authorMedeiros, Amanda Fernandes de
dc.contributor.authorCarvalho, Fabiana Maria Coimbra de
dc.contributor.authorLima, Vanessa Cristina Oliveira de
dc.contributor.authorSerquiz, Raphael Paschoal
dc.contributor.authorSerquiz, Alexandre Coelho
dc.contributor.authorSilbiger, Vivian Nogueira
dc.contributor.authorBortolin, Raul Hernandes
dc.contributor.authorSantos, Elizeu Antunes dos
dc.date.accessioned2024-02-02T12:44:14Z
dc.date.available2024-02-02T12:44:14Z
dc.date.issued2018
dc.description.resumoObjective: This study evaluated the effect of a protein, the isolated Trypsin Inhibitor (TTI) from Tamarindus indica L. seed, as a CCK secretagogue and its action upon food intake and leptin in obese Wistar rats. Methods: Three groups of obese rats were fed 10 days one of the following diets: Standard diet (Labina®) + water; High Glycemic Index and Load (HGLI) diet + water or HGLI diet + TTI. Lean animals were fed the standard diet for the 10 days. Food intake, zoometric measurements, plasma CCK, plasma leptin, relative mRNA expression of intestinal CCK-related genes, and expression of the ob gene in subcutaneous adipose tissue were assessed. Results: TTI decreased food intake but did not increase plasma CCK in obese animals. On the other hand, TTI treatment decreased CCK-1R gene expression in obese animals compared with the obese group with no treatment (p = 0.027). Obese animals treated with TTI presented lower plasma leptin than the non-treated obese animals. Conclusion: We suggest that TTI by decreasing plasma leptin may improve CCK action, regardless of its increase in plasma from obese rats, since food intake was lowestpt_BR
dc.identifier.citationCOSTA, Izael De Souza; MEDEIROS, Amanda Fernandes de; CARVALHO, Fabiana Maria Coimbra de; LIMA, Vanessa Cristina Oliveira de; SERQUIZ, Raphael Paschoal; SERQUIZ, Alexandre Coelho; SILBIGER, Vivian Nogueira; BORTOLIN, Raul Hernandes; MACIEL, Bruna Leal Lima; SANTOS, Elizeu Antunes dos. Satietogenic protein from tamarind seeds decreases food intake, leptin plasma and CCK-1r gene expression in obese wistar rats. Obesity Facts, [S.l.], v. 11, n. 6, p. 440-453, 2018. DOI: 10.1159/000492733. Disponível em: https://karger.com/ofa/article/11/6/440/239548/Satietogenic-Protein-from-Tamarind-Seeds-Decreases. Acesso em: 31 jan. 2024.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1159/000492733
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/57482
dc.languageenpt_BR
dc.publisherObesity Factspt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectCholecystokininpt_BR
dc.subjectTamarindus indica L.pt_BR
dc.subjectCCK-2R genept_BR
dc.subjectPCSK1 genept_BR
dc.subjectPre-Pro-CCK genept_BR
dc.subjectOb genept_BR
dc.titleSatietogenic protein from tamarind seeds decreases food intake, leptin plasma and CCK-1r gene expression in obese wistar ratspt_BR
dc.typearticlept_BR

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