Hippocampal Theta Oscillations and Cross-Frequency Coupling during Spatial Decision-Making

Belchior, Hindiael; Souza, Bryan; Santos, Vítor Lopes dos; Ribeiro, Sidarta Tollendal Gomes; Tort, Adriano Bretanha Lopes

Hippocampal Theta Oscillations and Cross-Frequency Coupling during Spatial Decision-Making

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dc.contributor.author	Belchior, Hindiael
dc.contributor.author	Souza, Bryan
dc.contributor.author	Santos, Vítor Lopes dos
dc.contributor.author	Ribeiro, Sidarta Tollendal Gomes
dc.contributor.author	Tort, Adriano Bretanha Lopes
dc.date.accessioned	2017-11-13T13:49:58Z
dc.date.available	2017-11-13T13:49:58Z
dc.date.issued	2014-09
dc.description.resumo	Introdução The processing of spatial and mnemonic information is believed to depend on hippocampal theta oscillations (512 Hz). However, in rats both the power and frequency of the theta rhythm are modulated by locomotor activity, which is a major confounding factor when estimating its cognitive correlates. Previous studies have suggested that hippocampal theta oscillations and its modulation of higher frequency rhythms support decisionmaking processes. Objetivos In the present study, we investigated to what extent spatial decisionmaking modulates hippocampal theta oscillations when controlling for variations in locomotion speed. In addition, we measured how the amplitude of lowgamma (2550 Hz), high-gamma (6090 Hz), and highfrequency oscillations (>100 Hz) is modulated by the phase of theta oscillations (crossfrequency coupling). Métodos We recorded local field potentials from the CA1 region of 5 male Wistar rats while animals had to choose one arm to enter for reward (goal) in a fourarm radial maze. The animals were previously trained to achieve 70% of correct choices and four sessions were used to the analyses. We then analyzed intervals of intertrial period (DELAY), decisionmaking (DM), and running to reward (RUN). Trials with similar locomotion speed were used to compare theta power across intervals. We measured crossfrequency coupling within each interval and temporally triggered to the end of DM. Resultados e Conclusões We observed prominent theta oscillations and strong phase modulation of gamma amplitude during DM interval of the task, which occurred in the center of the maze before animals deliberately ran through an arm towards goal location. In speed-controlled analyses, theta power and frequency were higher during the decision period when compared to either an intertrial delay period (also at the maze center), or to the period of running towards goal location (p<0.05, twoway ANOVA followed by Tukey's post hoc test). Moreover, theta activity was higher during decision intervals preceding correct choices than during decision intervals preceding incorrect choices (p<0.05, Student's ttest). Altogether, our data support a cognitive function for the hippocampal theta rhythm in spatial decisionmaking.	pt_BR
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/24247
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	Oscillations	pt_BR
dc.subject	Local field potential	pt_BR
dc.subject	Spatial choice	pt_BR
dc.subject	Speed	pt_BR
dc.subject	Radial maze	pt_BR
dc.title	Hippocampal Theta Oscillations and Cross-Frequency Coupling during Spatial Decision-Making	pt_BR
dc.type	conferenceObject	pt_BR