Association between brain morphology and electrophysiological features in Congenital Zika Virus Syndrome: a cross-sectional, observational study

Sequerra, Eduardo Bouth; Rocha, Antonio Jhones Lima da; Medeiros, Galtieri Otavio Cunha de; Moreira Neto, Manuel; Maia, Claudia Rodrigues Souza; Arrais, Nívia Maria Rodrigues; Bezerra, Mylena Taíse Azevedo Lima; Jeronimo, Selma Maria Bezerra; Barros Filho, Allan Kardec Duailibe; Sousa, Patrícia S; Melo, Aurea Nogueira de; Queiroz, Claudio Marcos Teixeira de

Association between brain morphology and electrophysiological features in Congenital Zika Virus Syndrome: a cross-sectional, observational study

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dc.contributor.author	Sequerra, Eduardo Bouth
dc.contributor.author	Rocha, Antonio Jhones Lima da
dc.contributor.author	Medeiros, Galtieri Otavio Cunha de
dc.contributor.author	Moreira Neto, Manuel
dc.contributor.author	Maia, Claudia Rodrigues Souza
dc.contributor.author	Arrais, Nívia Maria Rodrigues
dc.contributor.author	Bezerra, Mylena Taíse Azevedo Lima
dc.contributor.author	Jeronimo, Selma Maria Bezerra
dc.contributor.author	Barros Filho, Allan Kardec Duailibe
dc.contributor.author	Sousa, Patrícia S
dc.contributor.author	Melo, Aurea Nogueira de
dc.contributor.author	Queiroz, Claudio Marcos Teixeira de
dc.date.accessioned	2020-09-23T17:14:13Z
dc.date.available	2020-09-23T17:14:13Z
dc.date.issued	2020-08
dc.description.resumo	Background: Intrauterine infection with the Zika virus (ZIKV) has been connected to severe brain malformations, microcephaly, and abnormal electrophysiological activity. Methods: We describe the interictal electroencephalographic (EEG) recordings of 47 children born with ZIKV-derived microcephaly. EEGs were recorded in the first year of life and correlated with brain morphology. In 31 subjects, we tested the association between computed tomography (CT) findings and interictal epileptiform discharges (IED). In eighteen, CTs were used for correlating volumetric measurements of the brainstem, cerebellum, and prosencephalon with the rate of IED. Findings: Twenty-nine out of 47 (62%) subjects were diagnosed as having epilepsy. Those subjects presented epileptiform discharges, including unilateral interictal spikes (26/29, 90%), bilateral synchronous and asynchronous interictal spikes (21/29, 72%), and hypsarrhythmia (12/29, 41%). Interestingly, 58% of subjects with clinical epilepsy were born with rhombencephalon malformations, while none of the subjects without epilepsy showed macroscopic abnormalities in this region. The presence of rhombencephalon malformation was associated with epilepsy (odds ratio of 34; 95% CI: 2 - 654). Also, the presence of IED was associated with smaller brain volumes. Age-corrected total brain volume was inversely correlated with the rate of IED during sleep. Finally, 11 of 44 (25%) subjects presented sleep spindles. We observed an odds ratio of 0·25 (95% CI: 0·06 - 1·04) for having sleep spindles given the IED presence. Interpretation: The findings suggest that certain CT imaging features are associated with an increased likelihood of developing epilepsy, including higher rates of IED and impaired development of sleep spindles, in the first year of life of CZVS subjects	pt_BR
dc.identifier.citation	SEQUERRA, E. B. et al. Association between brain morphology and electrophysiological features in Congenital Zika Virus Syndrome: a cross-sectional, observational study. EclinicalMedicine, [S. l.], ago. 2020. Doi: 10.1016/j.eclinm.2020.100508. Disponível em: https://www.sciencedirect.com/science/article/pii/S2589537020302522. Acesso em: 23 set. 2020.	pt_BR
dc.identifier.doi	10.1016/j.eclinm.2020.100508
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/30180
dc.language	en	pt_BR
dc.publisher	Elsevier	pt_BR
dc.rights	Attribution-NonCommercial-NoDerivs 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/br/	*
dc.subject	Epilepsy	pt_BR
dc.subject	Hypsarrhythmia	pt_BR
dc.subject	Sleep spindles	pt_BR
dc.subject	Microcephaly	pt_BR
dc.title	Association between brain morphology and electrophysiological features in Congenital Zika Virus Syndrome: a cross-sectional, observational study	pt_BR
dc.type	article	pt_BR