Variants in SNCA gene are associated with parkinson’s disease risk and cognitive symptoms in a brazilian sample

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dc.contributor.authorGodeiro Junior, Clecio de Oliveira
dc.contributor.authorCampêlo, Clarissa Loureiro das Chagas
dc.contributor.authorCagni, Fernanda Carvalho
dc.contributor.authorFigueredo, Diego de Siqueira
dc.contributor.authorOliveira Junior, Luiz Gonzaga
dc.contributor.authorSilva Neto, Antônio Braz
dc.contributor.authorMacêdo, Priscila T.
dc.contributor.authorSantos, José R.
dc.contributor.authorIzídio, Geison Souza
dc.contributor.authorRibeiro, Alessandra Mussi
dc.contributor.authorAndrade, Tiago Gomes de
dc.contributor.authorSilva, Regina Helena
dc.contributor.authorID0000-0002-4312-1633pt_BR
dc.date.accessioned2023-07-05T16:53:13Z
dc.date.available2023-07-05T16:53:13Z
dc.date.issued2017-06-20
dc.description.resumoGenetic susceptibility contributes to the etiology of sporadic Parkinson’s Disease (PD) and worldwide studies have found positive associations of polymorphisms in the alphasynuclein gene (SNCA) with the risk for PD. However, little is known about the influence of variants of SNCA in individual traits or phenotypical aspects of PD. Further, there is a lack of studies with Latin-American samples. We evaluated the association between SNCA single nucleotide polymorphisms (single nucleotide polymorphisms, SNPs –rs2583988, rs356219, rs2736990, and rs11931074) and PD risk in a Brazilians sample. In addition, we investigated their potential interactions with environmental factors and specific clinical outcomes (motor and cognitive impairments, depression, and anxiety). A total of 105 PD patients and 101 controls participated in the study. Single locus analysis showed that the risk allele of all SNPs were more frequent in PD patients (p < 0.05), and the associations of SNPs rs2583988, rs356219, and rs2736990 with increased PD risk were confirmed. Further, the G-rs356219 and C-rs2736990 alleles were associated with early onset PD. T-rs2583988, G-rs356219 and C-2736990 alleles were significantly more frequent in PD patients with cognitive impairments than controls in this condition. In addition, in a logistic regression model, we found an association of cognitive impairment with PD, and the practice of cognitive activity and smoking habits had a protective effect. This study shows for the first time an association of SNCA polymorphism and PD in a South-American sample. In addition, we found an interaction between SNP rs356219 and a specific clinical outcome, i.e., the increased risk for cognitive impairment in PD patients.pt_BR
dc.identifier.citationGODEIRO JUNIOR, Clecio de Oliveira et al. Variants in SNCA Gene Are Associated with Parkinson’s Disease Risk and Cognitive Symptoms in a Brazilian Sample. Frontiers In Aging Neuroscience, [S.L.], v. 9, p. 1-13, 20 jun. 2017. Frontiers Media SA. http://dx.doi.org/10.3389/fnagi.2017.00198. Disponível em: https://www.frontiersin.org/articles/10.3389/fnagi.2017.00198/full. Acesso em: 05 jul. 2023.pt_BR
dc.identifier.doihttps://doi.org/10.3389/fnagi.2017.00198
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/53050
dc.languageenpt_BR
dc.publisherFrontiers in Aging Neurosciencept_BR
dc.subjectparkinson’s diseasept_BR
dc.subjectalpha-synucleinpt_BR
dc.subjectSNCA genept_BR
dc.subjectpolymorphismpt_BR
dc.subjectcognitive impairmentpt_BR
dc.subjectclinical assessmentpt_BR
dc.subjectBrazilpt_BR
dc.titleVariants in SNCA gene are associated with parkinson’s disease risk and cognitive symptoms in a brazilian samplept_BR
dc.typearticlept_BR

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