Human papillomavirus prevalence in women with normal cytology and with cervical cancer in Natal, Brazil

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dc.contributor.authorFernandes, José Verissímo
dc.contributor.authorMeissner, Rosely de Vasconcellos
dc.contributor.authorCarvalho, Maria Goretti F.
dc.contributor.authorFernandes, Thales A. A. de Medeiros
dc.contributor.authorAzevedo, Paulo Roberto Medeiros
dc.contributor.authorAzevedo, Judson Weber Verissímo de
dc.contributor.authorAraújo, Josélio Maria G. de
dc.date.accessioned2023-03-23T22:19:34Z
dc.date.available2023-03-23T22:19:34Z
dc.date.issued2011-08
dc.description.resumoThis study analyzed the prevalence of human papillomavirus (HPV) in cervical specimens obtained from women with normal cytology and with cervical cancer, in order to evaluate their correlation with health status and demographic characteristics, as well as sexual and reproductive activity in women treated at a cancer reference hospital in Natal, Northeast Brazil. A total of 158 women were divided into 2 groups according to their health status: group I comprised 110 women with normal cytology, and group II comprised 48 women with cervical cancer. Cervical smears were analyzed by cytological or histopathological examination for the detection of cytological alterations, and by PCR for HPV DNA detection using MY09/11 primers, followed by HPV genotyping by dot blot hybridization. Results showed overall HPV prevalence to be 24.5% in group I, with 19.1% of patients having single infection and 5.4% double infection. The HPV prevalence in group II was 85.4%, with 79.2% of patients having single and 6.2% double infection. We identified 10 different HPV genotypes, most with high oncogenic potential. HPV 16 was the most prevalent genotype in the two studied groups, followed by HPV 58 and HPV 18. High-risk HPV genital infection, chronological age, ethnicity, early onset of sexual and reproductive activities, multiple sexual partners and smoking increased the risk for cervical cancer.pt_BR
dc.identifier.citationFERNANDES, J. V. et al. Human papillomavirus prevalence in women with normal cytology and cervical câncer in Natal, Brazil. Molecular Medicine Reports, v. 4, p. 1321-1324, 2011. Disponível em: https://www.spandidos-publications.com/10.3892/mmr.2011.579. Acesso em: 08 dez. 2017.pt_BR
dc.identifier.issn1791-3004
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/51938
dc.languageenpt_BR
dc.publisherMolecular Medicine Reportspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectHuman papillomavirus,pt_BR
dc.subjectUterine cervical cancerpt_BR
dc.subjectRisk factorspt_BR
dc.titleHuman papillomavirus prevalence in women with normal cytology and with cervical cancer in Natal, Brazilpt_BR
dc.typearticlept_BR

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