On cross-frequency phase-phase coupling between theta and gamma oscillations in the hippocampus

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dc.contributor.authorScheffer-Teixeira, Robson
dc.contributor.authorTort, Adriano Bretanha Lopes
dc.date.accessioned2017-05-25T14:01:31Z
dc.date.available2017-05-25T14:01:31Z
dc.date.issued2016-12-07
dc.description.resumoPhase-amplitude coupling between theta and multiple gamma sub-bands is a hallmark of hippocampal activity and believed to take part in information routing. More recently, theta and gamma oscillations were also reported to exhibit phase-phase coupling, or n:m phase-locking, suggesting an important mechanism of neuronal coding that has long received theoretical support. However, by analyzing simulated and actual LFPs, here we question the existence of theta-gamma phase-phase coupling in the rat hippocampus. We show that the quasi-linear phase shifts introduced by filtering lead to spurious coupling levels in both white noise and hippocampal LFPs, which highly depend on epoch length, and that significant coupling may be falsely detected when employing improper surrogate methods. We also show that waveform asymmetry and frequency harmonics may generate artifactual n:m phase-locking. Studies investigating phase-phase coupling should rely on appropriate statistical controls and be aware of confounding factors; otherwise, they could easily fall into analysis pitfalls.pt_BR
dc.identifier.doi10.7554/eLife.20515
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/23074
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectoscillationspt_BR
dc.subjectthetapt_BR
dc.subjectgammapt_BR
dc.subjecthippocampuspt_BR
dc.titleOn cross-frequency phase-phase coupling between theta and gamma oscillations in the hippocampuspt_BR
dc.typearticlept_BR

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