Aqueous extract of brazilian berry (Myrciaria jaboticaba) peel improves inflammatory parameters and modulates Lactobacillus and Bifidobacterium in rats with induced-colitis

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dc.contributor.authorMaia, Juliana Kelly da Silva
dc.contributor.authorBatista, Ângela Giovana
dc.contributor.authorCazarin, Cinthia Baú Betim
dc.contributor.authorSoares, Edilene Siqueira
dc.contributor.authorBogusz Junior, Stanislau
dc.contributor.authorLeal, Raquel Franco
dc.contributor.authorHöfling, Maria Alice da Cruz
dc.contributor.authorMaróstica Junior, Mário Roberto
dc.date.accessioned2024-08-09T23:58:54Z
dc.date.available2024-08-09T23:58:54Z
dc.date.issued2019-11
dc.description.resumoNatural compounds could be a complementary alternative to inflammatory bowel disease (IBD) management. This study determined the effects of an aqueous extract of Myrciaria jaboticaba peel (EJP) (50 g L−1 ) on 2,4,6-trinitrobenzenesulfonic acid-induced colitis. Wistar rats were randomized into five groups: HC—healthy control, CC—colitis control, DC—drug control, SJ—short-term treatment with EJP, and LJ—long-term treatment with EJP. The EJP treatments reduced body weight loss, stool consistency score, and spleen enlargement. Gut microbiota was modulated through increased Lactobacillus and Bifidobacterium counts after EJP treatment. Short-chain fatty acids were also higher in the EJP treatment groups. The antioxidant enzyme activities were greater than CC or DC controls. Myeloperoxidase activity (LJ), inducible nitric oxide synthase (LJ/SJ), and intercellular adhesion molecule (SJ) levels were lower than in the CC group. EJP decreased histological scoring, mucosal thickness, and preserved the crypts and histological structure. Therefore, EJP showed beneficial effects and could be potentially used as an adjuvant in IBD treatmentpt_BR
dc.identifier.citationMAIA, Juliana Kelly da Silva; BATISTA, Ângela Giovana; CAZARIN, Cinthia Baú Betim et al. Aqueous extract of brazilian berry (Myrciaria jaboticaba) peel improves inflammatory parameters and modulates Lactobacillus and Bifidobacterium in rats with induced-colitis. Nutrients, [S.l.], v. 11, n. 11, p. 1-13, 15 nov. 2019. DOI: 10.3390/nu11112776. Disponível em: https://www.mdpi.com/2072-6643/11/11/2776. Acesso em: 8 mai. 2024.pt_BR
dc.identifier.doihttp://dx.doi.org/10.3390/nu11112776
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/59120
dc.languageenpt_BR
dc.publisherNutrientspt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectAntioxidantpt_BR
dc.subjectJaboticabapt_BR
dc.subjectGut inflammationpt_BR
dc.subjectMicrobiotapt_BR
dc.subjectInfusionpt_BR
dc.titleAqueous extract of brazilian berry (Myrciaria jaboticaba) peel improves inflammatory parameters and modulates Lactobacillus and Bifidobacterium in rats with induced-colitispt_BR
dc.typearticlept_BR

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